Table 5 Linear mixed-effects model results

Baseline age

−0.08

−0.12, −0.05

< 0.001

−0.06

−0.10, −0.03

0.001

Sex (ref.: female)

−0.14

−0.22, −0.06

0.001

−0.13

−0.21, −0.05

0.001

Education

0.14

0.11, 0.18

< 0.001

0.14

0.10, 0.17

< 0.001

Total study visits

0.15

0.12, 0.19

< 0.001

0.18

0.14, 0.22

< 0.001

Time

−0.67

−0.78, −0.57

< 0.001

−0.63

−0.73, −0.54

< 0.001

Class 2_PA (ref.: 1_{Low Life Space})

0.64

0.29, 0.99

< 0.001

0.67

0.35, 0.99

< 0.001

Class 3_{Low Avg} (ref.: 1_{Low Life Space})

0.31

0.13, 0.50

0.001

0.35

0.18, 0.52

< 0.001

Class 4_Balanced (ref.: 1_{Low Life Space})

0.70

0.52, 0.87

< 0.001

0.66

0.50, 0.82

< 0.001

Class 5_Social (ref.: 1_{Low Life Space})

0.85

0.43, 1.26

< 0.001

0.76

0.39, 1.13

< 0.001

Time × Class 2_PA

0.22

0.00, 0.44

0.049

0.24

0.04, 0.44

0.018

Time × Class 3_{Low Avg}

0.18

0.06, 0.30

0.004

0.21

0.10, 0.32

< 0.001

Time × Class 4_Balanced

0.34

0.22, 0.45

< 0.001

0.31

0.21, 0.42

< 0.001

Time × Class 5_Social

0.49

0.22, 0.77

< 0.001

0.43

0.19, 0.67

0.001

AD

-

-

-

−0.22

−0.27, −0.17

< 0.001

CVD

-

-

-

−0.07

−0.12, −0.02

0.004

LBD (ref.: no.)

-

-

-

−0.27

−0.39, −0.16

< 0.001

HS/TDP-43

-

-

-

−0.11

−0.16, −0.06

< 0.001

Time × AD

-

-

-

−0.14

−0.17, −0.11

< 0.001

Time × CVD

-

-

-

−0.03

−0.06, 0.00

0.085

Time × LBD

-

-

-

−0.12

−0.19, −0.05

0.002

Time × HS/TDP-43

-

-

-

−0.05

−0.08, −0.02

0.001