Table 1 Clinical and demographic characteristics of the participants
Characteristics of the participantsa | First year (n = 122) | Second year (n = 99) | Third year (n = 61) |
|---|---|---|---|
Demographic characteristics | |||
 Age, years, median (IQR) | 75.50 (71.00–80.00) | 76.00 (72.00–80.00) | 76.00 (71.00–80.00) |
 Sex (male:female) | 54:68 | 44:55 | 29:32 |
 Education duration, median (IQR) | 12.00 (9.00–12.00) | 12.00 (9.00–12.00) | 12.00 (9.00–12.00) |
 BMI, kg/m2, median (IQR) | 23.19 (21.28–24.93) | 23.46 (21.66–25.37) | 23.60 (22.00–25.32) |
 ApoE4 (negative:positive)b | 105:17 | 85:14 | 49:12 |
 Ever drinking (none:sometimes:everyday) | 78:23:21 | 62:20:17 | 40:14:7 |
 Ever smoking (none:sometimes:everyday) | 117:0:5 | 95:1:3 | 60:0:1 |
Wearable sensor data | |||
 Steps/day, median (IQR) | 4425.21 (2839.88–6364.50) | 4168.86 (2552.55–5886.65) | 4008.35 (2542.67–5420.50) |
 Light physical activity, min/day, median (IQR) | 16.46 (10.55–28.64) | 18.79 (10.07–29.06) | 16.05 (8.71–23.21) |
 Moderate-to-vigorous physical activity, min/day, median (IQR) | 21.46 (11.16–35.13) | 17.82 (10.76–29.95) | 15.30 (10.46–29.83) |
 Sedentary behavior, min/day, median (IQR) | 788.35 (739.65–830.27) | 779.83 (724.03–839.19) | 776.26 (713.50–842.21) |
 TST, min/day, median (IQR) | 400.12 (355.96–445.53) | 401.85 (357.71–455.97) | 412.75 (371.41–474.67) |
 Sleep efficiency/day, median (IQR) | 0.96 (0.93–0.97) | 0.96 (0.94–0.98) | 0.96 (0.94–0.97) |
 Awakening time count, times/day, median (IQR) | 0.47 (0.29–0.72) | 0.43 (0.29–0.68) | 0.47 (0.25–0.68) |
 Naptime, min/day, median (IQR) | 35.50 (19.23–59.73) | 37.77 (23.43–63.95) | 47.27 (25.71–68.78) |
 Nap efficiency/day, median (IQR) | 0.99 (0.93–1.00) | 0.98 (0.95–1.00) | 0.96 (0.94–1.00) |
 Awakening time count during nap, times/day, median (IQR) | 0.03 (0.00–0.10) | 0.03 (0.00–0.08) | 0.04 (0.02–0.08) |
 Heart rate, beats/min, median (IQR) | 63.48 (59.63–68.79) | 63.05 (59.00–69.20) | 62.83 (58.97–69.88) |
 Conversation time, min/day, median (IQR) | 213.79 (173.46–270.91) | 221.59 (183.01–279.64) | 221.72 (176.75–271.07) |
 ActiveScale, times/day, median (IQR) | 4.63 (3.18–6.70) | 4.59 (2.87–6.80) | 3.84 (2.46–5.91) |
Others | |||
 MoCA-J score, median (IQR) | 22.00 (19.00–25.00) | 23.00 (20.00–26.00) | 23.00 (19.00–25.00) |
 Mean SUVR on PiB, median (IQR) | 0.92 (0.83–1.32) | 0.90 (0.83–1.37) | 0.90 (0.82–1.49) |
 PiB-PET (negative:positive) | 94:28 | 75:24 | 45:16 |