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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer’s polygenic risk reveals autobiographical deficits and cingulate cortex correlates

Fig. 1

A Histogram represents the frequency of Alzheimer’s disease polygenic risk score (AD-PRS) estimated in 4504 participants as part of the PROTECT cohort. X-axis is standardised with a mean of zero and a standard deviation of 1. Grey bars reflect participants in the wider cohort, while blue and red horizontal lines represent the AD-PRS of individual participants in the present study. All participants had an AD-PRS at least 2 standard deviations over or under the cohort mean and were in the lowest (1) or highest (10) AD-PRS decile respectively. B Power (y-axis) is the proportion of significant associations from a simulated data set (from 1000 replicates), for an opportunistic sample (red line) and the recall-by-genotype sample (blue line). Crosses and black line intersections show power for our current sample (for recall-by-genotype; 85% power and opportunistic; 21% power) and the comparable sample size for the same power (N EFFECTIVE = 90). X-axis reflects sample size on a log10 scale

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Alzheimer's Research & Therapy

ISSN: 1758-9193