Table 4 Cognitive trajectories in different treatment groups
Crude model | Adjusted model | |||||
|---|---|---|---|---|---|---|
Coeff. | 95% CI | p-value | Coeff. | 95% CI | p-value | |
Statin users (ref. non-users of statins) | ||||||
Average | 0.05 | -0.12; 0.21 | 0.596 | 0.01 | -0.02; 0.01 | 0.670 |
Per year | 0.15 | 0.04; 0.26 | 0.007 | 0.21 | 0.12; 0.32 | <0.001 |
After 3 years | 0.50 | 0.21; 0.80 | 0.001 | 0.63 | 0.33; 0.94 | <0.001 |
Simvastatin users (ref.- atorvastatin users) | ||||||
Average | -0.22 | -0.48; 0.03 | 0.090 | -0.03 | -0.07; 0.01 | 0.105 |
Per year | 0.30 | 0.07; 0.53 | 0.010 | 0.35 | 0.03; 0.67 | 0.035 |
After 3 years | 0.68 | 0.02; 1.34 | 0.043 | 1.01 | 0.06; 1.97 | 0.038 |
Simvastatin users (ref. rosuvastatin users) | ||||||
Average | -0.48 | -1.11; 0.14 | 0.131 | -0.03 | -0.09; 0.03 | 0.349 |
Per year | 0.48 | 0.08; 0.87 | 0.018 | 0.35 | 0.09; 0.61 | 0.008 |
After 3 years | 0.95 | -0.12; 2.01 | 0.081 | 1.03 | 0.26; 1.80 | 0.009 |
Lipophilic statin users (ref.- hydrophilic statin users) | ||||||
Average | -0.04 | -0.55; 0.48 | 0.883 | 0.01 | -0.04; 0.04 | 0.953 |
Per year | 0.03 | -0.41; 0.47 | 0.902 | 0.08 | -0.25; 0.41 | 0.635 |
After 3 years | 0.04 | -1.19; 1.28 | 0.944 | 0.24 | -0.75; 1.24 | 0.632 |
Fungal statin users (ref. synthetic statin users) | ||||||
Average | -0.38 | -0.64; -0.11 | 0.006 | -0.03 | -0.07; 0.01 | 0.067 |
Per year | 0.24 | 0.02; 0.46 | 0.035 | 0.28 | -0.02; 0.59 | 0.071 |
After 3 years | 0.34 | -0.30; 0.98 | 0.301 | 0.82 | -0.09; 1.72 | 0.079 |
Non-statin lipid-lowering medication users (ref. statin users) | ||||||
Average | 0.07 | -0.78; 0.93 | 0.866 | -0.006 | -0.74; 0.09 | 0.889 |
Per year | 0.74 | 0.90; -2.37 | 0.896 | 0.40 | -1.33; 2.13 | 0.654 |
After 3 years | 2.28 | -2.34; 6.90 | 0.333 | 1.19 | -3.35; 6.34 | 0.649 |