Table 3 Medication use in patients with AD and mixed dementia
Total cohort (n= 15,586) | Statin users (n = 10,869) | Non-users of statins (n = 4717) | p-value | |
|---|---|---|---|---|
Cardiac drugs | 2620 (16.8) | 1993 (18.3) | 627 (13.3) | <0.001 |
Vasoprotectives | 182 (1.2) | 108 (1.0) | 74 (1.6) | <0.01 |
Antiplatelets | 8324 (53.4) | 6444 (59.3) | 1880 (39.9) | <0.001 |
Anticoagulants | 2405 (15.4) | 1733 (15.9) | 672 (14.2) | 0.01 |
Antipsychotics | 703 (4.5) | 447 (4.1) | 256 (5.4) | <0.001 |
Antidepressants | 4736 (30.4) | 3261 (30.0) | 1475 (31.3) | 0.11 |
Hypnotics | 3416 (21.9) | 2266 (20.8) | 1150 (24.4) | <0.001 |
Anxiolytics | 2064 (13.2) | 1365 (12.6) | 699 (14.8) | <0.001 |
Acetylcholinesterase inhibitors | 4591 (29.5) | 3301 (30.4) | 1290 (27.3) | <0.001 |
Memantine | 969 (6.2) | 683 (6.3) | 286 (6.1) | 0.60 |
Vitamin D | 376 (2.4) | 248 (2.3) | 128 (2.7) | 0.11 |
Diuretics | 4294 (27.6) | 3136 (28.9) | 1158 (24.5) | <0.001 |
Beta blockers | 7248 (46.5) | 5481 (50.4) | 1767 (37.5) | <0.001 |
Calcium channel blockers | 4347 (27.9) | 3257 (30.0) | 1090 (23.1) | <0.001 |
Antihypertensives | 12 373 (79.4) | 9119 (83.9) | 3254 (69.0) | <0.001 |
Insulin | 1599 (10.3) | 1247 (11.5) | 352 (7.5) | <0.001 |
Non-insulin antidiabetics | 3112 (20.0) | 2403 (22.1) | 709 (15.0) | <0.001 |
Non-steroidal anti-inflammatory drugs | 1012 (6.5) | 705 (6.5) | 307 (6.5) | 0.96 |
Bisphosphonate | 810 (5.2) | 562 (5.2) | 248 (5.3) | 0.82 |
Simvastatin | 8235 (52.8) | 8235 (75.8) | 0 | N/A |
Atorvastatin | 2210 (14.2) | 2210 (20.3) | 0 | N/A |
Rosuvastatin | 289 (1.9) | 289 (2.7) | 0 | N/A |
Pravastatin | 261 (1.7) | 261 (2.4) | 0 | N/A |
Fluvastatin | 11 (0.1) | 11 (0.1) | 0 | N/A |
Non-statin hypolipemics | 296 (1.9) | 137 (1.3) | 159 (3.4) | <0.001 |
Fibrate | 76 (0.5) | 28 (0.3) | 48 (1.0) | <0.001 |
Resin | 54 (0.3) | 8 (0.1) | 46 (1.0) | <0.001 |
Ezetimibe | 170 (1.1) | 102 (0.9) | 68 (1.4) | 0.01 |