Study design characteristics | Description of characteristics |
---|---|
Population | AD and mixed dementia patients with hyperlipidaemia |
Outcome | MMSE points |
Statistical model | Linear mixed-effects regression models with inverse probability of drop out weighting |
Medication use | Time-updated exposure • Primary analysis: average DDD during the 6-month period preceding index date • Secondary analysis: yes/no use of medication during the 6-month period preceding index date |
Analysis | Primary: 1. Statin users vs non-users of statins Secondary: 2. Simvastatin vs atorvastatin users 3. Simvastatin vs rosuvastatin users 4. 1Lipophilic vs 2hydrophilic statins users 5. 3Fungal vs 4synthetic statins users 6. Non-statin lipid lowering medication users vs statin users |
Covariates | Age, gender, diagnosis year, residency, care unit, comedications, comorbidities |
Stratified analyses | 1) Gender, 2) age (split at mean age at index date) |
Sensitivity analyses | 1) Multiple imputations of MMSE, 2) incident users |