Skip to main content

Table 4 Overall summary and schedule of the Structured Multimodal lifestyle Intervention (SMLI) Included in the FINGER 2.0 Multimodal Intervention

From: A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol

SMLI structured programmesa

Activity

Study months

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

Diet

Group sessions

X4 (1.5–2 h)

X1 (1.5–2 h)

X2 (1.5–2 h)

      

Individual consultations

X2 (45–60 min)

X1 (45–60 min)

Physical activity

Resistance and balance training (gym)

 

Once a week; gradually increasing from 30–45 min to 30–60, 45–60, and 60 min (by month 6)

Resistance and balance training (online)

  

Once a week (duration as above)

Twice per week (duration as above)

Independent aerobic exercise

  

2–4 times per week (30–60 min)

3–5 times week (depending on the number of group training sessions, to have 1 day of rest)

Cognitive intervention

Group sessions

   

X6 (1–1.5 h)

              

Independent training

     

72 sessions (10–15 min); frequency: 3 times a week

Break 3–6 months

72 sessions (10–15 min); frequency: 3 times a week

 

Monitoring of cardiovascular/metabolic risk factors

Practical consultation

  

1

     

1

        

1

      

Medical consultation

  

1

  

1

     

1

            
  1. a The intervention is administered by applying common principles and procedures across sites, but always based on the unique risk profile of individual participants. Additionally, recommendations for diet and management of cardiovascular/metabolic risk factors follow the local/national guidelines, leading to local adaptations and some differences in the way these two components are delivered across sites. Furthermore, when administering the intervention, daily life/habits, needs, living location/conditions and cultural/socio-economic context are considered, both at participant and site level, to ensure tailoring, and support adherence. Continuous communication and participant feedback at 12 months will also help address any potential adherence concerns during the study. Overall, this allows for a highly tailored but still sufficiently harmonised intervention within and across sites. Participants randomised to the SMLI are assigned to a specific Intervention Participation Group (n ~ 5–10) and group meetings/exercise session will be organised as much as possible to include the members of a specific Intervention Participation Group. If necessary due to logistics and time availability, participants can attend group meetings/sessions in other Intervention Participation Groups