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Table 1 Demographic, clinical and neuropsychological assessment performance for all groups

From: The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia

 

svPPA

nfvPPA

lvPPA

Control

Magnitude of group effect

Direction of post-hoc effect

N

13

15

19

43

-

-

Recruitment site (C/M/S)

5/1/7

9/2/4

5/2/12

23/0/20

-

-

Sex (M: F)

7:6

10:5

6:13

22:21

\(\chi\) 2(3) = 4.3; p = .22

-

Age (years)

66.3 (5.4)

71.2 (5.6)

70.6 (7.7)

61(9.4)

F(3,86) = 9.4; p < .001; \({\eta }_{p}^{2}\)=.25[.1–1]

Control < lvPPA, nfvPPA

Education (years)

18.9 (2.3)

17.2 (1.9)

19.2 (3)

21.1 (3)

F(3,86) = 7.9; p < .001; \({\eta }_{p}^{2}\)=.22[.09–1]

nfvPPA < Controls

Handedness (R: L)

13:0

13:2

18:1

39:4

\(\chi\) 2(3) = 2; p = .56

-

Symptom duration (years)

1.6 (1.9)

.7 (.7)

3.3 (5.5)

-

F(2,44) = 2.5; p = .09; \({\eta }_{p}^{2}\)=1[0–1]

-

Cognitive and language assessments

MLSE total score (100)

73.4 (12.6)

64.2 (24.4)

79.5 (5.1)

98.6 (1.7)

F(3,86) = 42.7; p < .001; \({\eta }_{p}^{2}\)=.6[.49–1]

Patients < Controls

ACE-III Total (100)

50.8 (19.1)

55 (24.5)

54.8 (8.8)

-

F(2,35) = .22; p = .8; \({\eta }_{p}^{2}\)=.01[0–1]

-

ACE-III Attention total (18)

10.7 (4.5)

11.8 (5.2)

14.6(2.1)

-

F(2,35) = 2.7; p = .07; \({\eta }_{p}^{2}\)=.014[0–1]

-

ACE-III Memory total (26)

7.8 (6.5)

11.9 (8.2)

9.2 (4.5)

-

F(2,35) = 1.2; p = .2; \({\eta }_{p}^{2}\)=.07[0–1]

-

ACE-III Fluency total (14)

3.3 (2.5)

3.4 (3.2)

4.4 (1.8)

-

F(2,35) = .6; p = .53; \({\eta }_{p}^{2}\)=.04[0–1]

-

ACE-III Language total (26)

17.5 (6.2)

16.2 (7)

11.6 (3.2)

-

F(2,35) = 3.4; p = .042; \({\eta }_{p}^{2}\)=.16[0–1]

svPPA < lvPPA

ACE-III Visuospatial total (16)

11.3 (3)

11.5 (5.2)

14.8 (1.4)

-

F(2,35) = 3.5; p = .039; \({\eta }_{p}^{2}\)=.17[0–1]

lvPPA < svPPA

  1. Maximum test scores reported in brackets. For recruitment site, C Cambridge, M Manchester, S St. George’s, University of London. For all groups, mean and standard deviations reported; \(\chi\) 2 = Chi-square value; for magnitude of group effect, exact \(\chi\) 2/F-statistics, exact p-values (unless p < .001), and effect size (\({\eta }_{p}^{2}\)) values reported; for group effect statistical comparisons, p-values are in bold if p ≤ .05; post hoc alpha threshold set at p ≤ .025
  2. ACE-III Addenbrooke’s Cognitive Examination-III, MLSE Mini Linguistic State Examination, lvPPA logopenic variant primary progressive aphasia, nfvPPA nonfluent variant primary progressive aphasia, svPPA semantic variant primary progressive aphasia