Fig. 3

Regions of grey matter (left panel) and white matter (right panel) changes that correlate with general cognition component. PCA, grey, and white matter analyses were conducted in the combined PPA group (N = 47). For VBM, coloured voxels indicate regions that emerged as significant in the voxel-based morphometry analyses at a threshold of p < .001 uncorrected for multiple comparisons with a cluster threshold of 50 contiguous voxels. Age, total intracranial volume, and testing site were included as covariates in the analyses. Clusters are overlaid on the MNI standard brain with x, y, and z co-ordinates reported in MNI standard space. For NBS, black spheres indicate cortical nodes whose edges (gold lines) emerged significant at p < .001 uncorrected for multiple comparisons. Edge thickness corresponds to corresponding effect size (i.e., t-value). Age and testing site were included as covariates in the analyses. L left, R right, PCA principal component analysis, PPA primary progressive aphasia, AG angular gyrus, SMA supplementary motor area, SFG superior frontal gyrus, Olf. olfactory cortex, PCC posterior cingulate cortex, VBM voxel-based morphometry, NBS network based statistics