Table 2 Description of the latent classes of subjective cognitive complaints stratified by objective cognitive trajectory, in our subsample of MEMENTO study participants
Stratum | Stratum #1 High and increasing MMSE (n = 1044) | Stratum #2 Subtle decline in MMSE scores (n = 445) | Stratum #3 Steep decrease in MMSE scores (n = 259) | |||
|---|---|---|---|---|---|---|
Cognitive complaint trajectory | Moderate and increasing complaint | Mild and decreasing complaint | Moderate and increasing complaint | Mild and decreasing complaint | Stable moderate complaint | Stable mild complaint |
N (% of the stratum) | 476 (45.6) | 568 (54.4) | 295 (66.4) | 150 (33.6) | 155 (59.8) | 104 (40.1) |
Cognitive complaint score at baseline [/30; mean (SD)] | 15.04 (5.40) | 9.13 (5.03) | 15.02 (5.33) | 9.00 (5.10) | 16.15 (4.27) | 7.79 (4.11) |
Age at baseline [years; mean (SD)] | 68.99 (8.91) | 69.96 (8.04) | 70.78 (8.94) | 71.75 (7.98) | 73.13 (8.26) | 74.73 (7.43) |
Sex [female; n (%)] | 312 (65.5) | 356 (62.7) | 186 (63.1) | 89 (59.3) | 95 (61.3) | 53 (51.0) |
Education [low; n (%)] | 118 (24.8) | 143 (25.2) | 140 (47.5) | 64 (42.7) | 82 (52.9) | 61 (58.7) |
Dementia incidence rate [per 1000 person-years] | 2.82 | 3.99 | 22.29 | 23.98 | 231.06 | 308.67 |
Blood pTau/Aβ42 at baseline [pg/mL; mean (SD)] | 0.10 (0.15) | 0.10 (0.29) | 0.12 (0.15) | 0.09 (0.07) | 0.15 (0.12) | 0.20 (0.29) |
Cortical thickness at baseline [cm3; mean (SD)] | 2.35 (0.10) | 2.34 (0.09) | 2.33 (0.10) | 2.32 (0.09) | 2.28 (0.09) | 2.27 (0.10) |
APOE genotype [noncarrier; n (%)] | 363 (76.3) | 432 (76.1) | 201 (68.1) | 47 (31.3) | 78 (50.3) | 52 (50.0) |
Comorbidity-polypharmacy at baseline [mean (SD)] | 7.24 (5.03) | 6.24 (4.11) | 8.53 (4.95) | 7.03 (4.78) | 7.46 (4.33) | 6.51 (4.55) |
Depression score at baseline [mean (SD)] | 1.61 (2.87) | 0.84 (2.19) | 2.20 (3.70) | 0.65 (1.94) | 1.43 (2.70) | 2.08 (3.33) |
Anxiety score at baseline [mean (SD)] | 2.01 (3.37) | 1.26 (2.82) | 2.32 (3.22) | 1.28 (2.72) | 2.01 (3.15) | 2.69 (4.35) |
Social network [Nb of close relationships; mean (SD)] | 5.91 (4.93) | 6.78 (5.76) | 5.77 (5.51) | 6.53 (9.23) | 6.47 (5.68) | 7.13 (7.02) |