Table 3 Associations of polygenic score for general cognition with annual changing rates of the cognitive function measurements over 8 years of follow-up

Word recall

 Genomic model

0.038 (0.002)

< 0.0001

0.035

0.013 (0.004)

0.0004

0.010

 Genomic, age and sex adjusted base model

0.041 (0.002)

< 0.0001

0.299

0.012 (0.003)

0.0004

0.172

 Base model + baseline word recall

0.016 (0.001)

< 0.0001

0.673

0.004 (0.002)

0.07

0.588

 Base model + mean word recall

0.012 (0.001)

< 0.0001

0.708

0.003 (0.002)

0.19

0.616

 Base model + baseline word recall, and APOE

0.016 (0.001)

< 0.0001

0.674

0.004 (0.002)

0.07

0.589

 Full model

0.012 (0.001)

< 0.0001

0.692

0.002 (0.002)

0.35

0.619

Mental status

 Genomic model

0.039 (0.002)

< 0.0001

0.072

0.024 (0.007)

0.0008

0.051

 Genomic, age and sex adjusted base model

0.040 (0.002)

< 0.0001

0.159

0.024 (0.007)

0.0005

0.139

 Base model + baseline mental status

0.012 (0.001)

< 0.0001

0.662

0.003 (0.004)

0.43

0.765

 Base model + mean mental status

0.010 (0.001)

< 0.0001

0.659

0.004 (0.004)

0.35

0.758

 Base model + baseline mental status, and APOE

0.012 (0.001)

< 0.0001

0.666

0.003 (0.004)

0.41

0.767

 Full model

0.010 (0.001)

< 0.0001

0.675

0.001 (0.004)

0.72

0.784

Total cognitive function

 Genomic model

0.082 (0.004)

< 0.0001

0.064

0.044 (0.013)

0.0006

0.039

 Genomic, age and sex adjusted base model

0.085 (0.004)

< 0.0001

0.265

0.043 (0.012)

0.0003

0.187

 Base Model + baseline total cognitive function

0.024 (0.003)

< 0.0001

0.704

0.008 (0.007)

0.25

0.751

 Base Model + mean total cognitive function

0.017 (0.003)

< 0.0001

0.715

0.005 (0.007)

0.45

0.762

 Base Model + baseline total cognitive function, and APOE

0.024 (0.003)

< 0.0001

0.708

0.008 (0.007)

0.26

0.754

 Full model

0.019 (0.003)

< 0.0001

0.722

0.005 (0.007)

0.48

0.776