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Fig. 8 | Alzheimer's Research & Therapy

Fig. 8

From: Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells

Fig. 8

Blockade of A2AR Remodeled NMDA Receptors in abGCs of APP/PS1 Mice. A Pharmacologically isolated NMDAR-mediated EPSCs from granule cells recorded before (gray), after the application of ifenprodil (red), and followed by APV (black). Scale bar = 100 ms and 20 pA. B Summary of the inhibition of NMDAR-mediated EPSCs by ifenprodil, indicating the contribution of NR2B-containing NMDARs to the total NMDAR-mediated EPSCs in abGCs and mGCs. C Pharmacologically isolated NMDAR-mediated EPSCs from granule cells recorded before (gray), after the application of NVP-AAM077 (red), and followed by APV (black). Scale bar = 100 ms and 20 pA. D Summary of the inhibition of NMDAR-mediated EPSCs by NVP-AAM077, indicating the contribution of NR2A-containing NMDARs to the total NMDAR-mediated EPSCs in abGCs and mGCs. E Histograms showing the ratio between NR2B-mediated EPSCs and NR2A-mediated EPSCs. Treatment with SCH58261 reversed the decrease in the ratio observed in abGCs from APP/PS1 mice. F Histograms showing the relative expression of NR2B and NR2A mRNA in 1.5 mpi abGCs or mGCs. Treatment with SCH58261 reversed the decrease in the NR2B / NR2A mRNA ratio observed in abGCs from APP/PS1 mice. Data are presented as the mean ± SEM, n = 10 neurons per group, with each neuron from an individual animal, **p < 0.01, ***p < 0.001 by one-way ANOVA followed by Sidak’s post-hoc test

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Alzheimer's Research & Therapy

ISSN: 1758-9193