Fig. 4
Blockade of A2AR Recovered LTP of the DG Region in APP/PS1 Mice. A Schematic illustration of field excitatory postsynaptic potential (fEPSP) recordings in the DG. B Schematic illustration of theta-burst stimulation for the induction of LTP. C fEPSPs of the DG region were recorded in acute mouse hippocampal slices. The mean amplitude of fEPSPs, expressed as a percentage of the baseline level, is plotted for the WT group and the WT + SCH58261 group. It shows the 10 min of baseline recording and 60 min of post-TBS (arrow) recording. Responses were evoked and collected at a rate of 1/60 s. Insets represent typical fEPSPs recorded before (black) and 50 min after (red) TBS. Scale bar = 5 ms and 0.5 mV. D Summary of experiments showing LTP recorded from the DG region in slices from WT mice, APP/PS1 mice, and SCH58261-treated APP/PS1 mice. E–F The average amplitude of fEPSPs during the first 10 min (E) and the last 10 min (F) post-TBS was significantly decreased in APP/PS1 mice. However, this decrease was significantly reversed by SCH58261 treatment. Data are presented as the mean ± SEM, n = 10 animals per group, **p < 0.01 by one-way ANOVA followed by Sidak's post-hoc test