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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells

Fig. 1

A2AR Overexpression in the Hippocampus of APP/PS1 Mice. A Representative images of Aβ plaques in the dentate gyrus (DG) and entorhinal cortex (EC) from 4, 6, and 12-month-old APP/PS1 mice. Prominent Aβ plaques were observed in 6 and 12-month-old APP/PS1 mice, but not in 4-month-old APP/PS1 mice. Scale bar = 500 μm. B Western blots showed a significant upregulation in protein expression of A2AR in the hippocampus of APP/PS1 mice compared to wild-type (WT) mice, n = 4 animals per group. C mRNA levels of A2AR were significantly increased in the hippocampus of APP/PS1 mice compared to WT mice, n = 5 animals per group. D Representative images of A2AR immunohistochemical staining in the DG of mice. Scale bar = 100 μm. Inserts show locally enlarged images of indicated areas by the dashed line boxes, n = 5 animals per group. Data are presented as the mean ± SEM, *p < 0.05 and **p < 0.01 by Student’s t-test

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Alzheimer's Research & Therapy

ISSN: 1758-9193