Fig. 2

Associations between serum immunoglobulins and neuroimaging markers. Associations are presented as adjusted mean differences (95% confidence interval) for 3139 study participants. Model II is displayed, which is adjusted for age, sex, cohort, intracranial volume, time difference, smoking status, alcohol consumption, educational attainment and APOE-ε4 carriership. All neuroimaging markers and serum immunoglobulins were standardized. Models of WMH, FA and MD were additionally corrected for normal appearing white matter volume. Abbreviations: TBV = total brain volume, GM = gray matter volume, WM = white matter volume, HV = hippocampal volume, WMH = white matter hyperintensities, FA = fractional anisotropy, MD = mean diffusivity, SD = standard deviation, CI = confidence interval. No associations reached statistical significance, after accounting for multiple testing. A detailed overview of all models (I-III) can be found in Supplementary Table 2