Fig. 1

Overall associations between serum immunoglobulins and plasma biomarkers of dementia. Associations are presented as adjusted mean differences (95% confidence interval) for 3455 study participants. Model II is displayed, which is adjusted for age, sex, study cohort, time difference, smoking status, alcohol consumption, educational attainment and APOE-ε4 carriership. Abbreviations: NfL = neurofilament light chain, t-tau = total tau, SD = standard deviation, CI = confidence interval. No associations reached statistical significance, after accounting for multiple testing using the false discovery rate. A detailed overview of all models (I-III) can be found in Supplementary Table 1