Table 1 Genome-wide association (P < 5 × 10−8) of CR score derived from different cognitive assessments. The 4 symbols per gene in the “Direction” column signify the direction of effect in each cohort in the following order: ADC1, ADC2, OMNI, GSA. The symbol ? indicates that the SNP was not available in the dataset after MAF > 0.01 thresholding,—indicates a negative direction of effect (risk effect of alternate allele), and + indicates a positive direction of effect (protective effect of alternate allele)
From: Quantitative estimate of cognitive resilience and its medical and genetic associations
CR score | Chr | Position | rs ID | Closest gene | Ref | Alt | Alt Allele Freq | Direction | β (SE) | P-value |
|---|---|---|---|---|---|---|---|---|---|---|
ANIMALS | 8 | 2201568 | rs182140222 | MYOM2 < > LOC101927815 | C | G | 0.011 | ??? + | 0.096 (0.015) | 6.47 × 10−11 |
LOGIMEM | 19 | 44908684 | rs429358 | APOE | T | C | 0.274 | –– | − 0.016 (0.003) | 5.84 × 10−10 |
NACCUDSD | 3 | 86714172 | rs148691207 | LINC02070 < > VGLL3 | G | A | 0.015 | + + + + | 0.054 (0.010) | 1.38 × 10−08 |
NACCUDSD | 6 | 170624470 | NA | LOC101929692 | AC | A | 0.020 | + ?? + | 0.161 (0.021) | 4.44 × 10−14 |
NACCUDSD | 19 | 44908684 | rs429358 | APOE | T | C | 0.274 | –– | − 0.017 (0.002) | 1.41 × 10−12 |