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Table 7 Results of the group-wise LMM analysis performed to evaluate change in global EEG measures over time (in months) in Aβ + MCI or AD dementia patients. Regression coefficients (β) and 95% confidence intervals (CI) of the Time effects are reported. Estimates for the Group*Time interaction effects, as well as estimates adjusted for age, sex and medication use are presented in Additional file 2 (Table S6)

From: Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials

Region

Measure

Frequency band

Disease stage

β

95% CI

p-value

Global

Relative power

Theta

MCIb

1.8E-03

1.1E-03

2.6E-03

 < .001***

 

AD dementiab

9.3E-04

-4.6E-05

1.9E-03

0.07

Alpha1

MCIb

-2.4E-04

-1.3E-03

7.8E-04

0.64

 

AD dementiab

-9.9E-04

-2.2E-03

1.8E-04

0.10

Alpha2

MCIa

-1.9E-04

1.0E-03

6.2E-04

0.64

 

AD dementiaa

-4.8E-04

-1.4E-03

4.6E-04

0.32

Beta

MCIa

-7.0E-04

-1.3E-03

-5.1E-05

 < .05*

 

AD dementiaa

-3.2E-04

-1.1E-03

4.3E-04

0.40

AEC-c

Alpha

MCIa

-1.7E-04

-5.9E-04

2.5E-04

0.42

 

AD dementiaa

1.3E-05

-4.7E-04

5.0E-04

0.96

Beta

MCIa

-3.4E-05

-1.9E-04

1.2E-04

0.67

 

AD dementiaa

-9.1E-05

-2.7E-04

9.3E-05

0.33

PLI

Theta

MCIa

1.3E-04

-3.2E-04

5.8E-04

0.58

 

AD dementiaa

1.8E-04

-3.5E-04

7.0E-04

0.50

PE

Theta

MCIa

-5.5E-05

-2.6E-04

1.5E-04

0.60

 

AD dementiaa

-2.3E-04

-4.6E-04

1.2E-05

0.06

wSMI

Theta

MCIa

2.9E-06

-1.5E-04

1.6E-04

0.97

 

AD dementiaa

1.5E-04

-3.3E-05

3.3E-04

0.11

JPEinv

Theta

MCIa

-5.6E-06

-1.4E-04

1.3E-04

0.93

 

AD dementiaa

-1.2E-04

-2.8E-04

3.4E-05

0.12

  1. AEC-c Corrected amplitude envelope correlation, PLI Phase lag index, PE Permutation entropy, wSMI Weighted symbolic mutual information, JPEinv Inverted joint permutation entropy
  2. *p<.05, **p<.01, ***p<.001
  3. aRandom intercept on subject level
  4. bRandom intercept and random slope on subject level