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Table 6 Results of the group-wise LMM analysis performed to evaluate change in temporal EEG measures over time (in months) in Aβ + MCI or AD dementia patients. Regression coefficients (β) and 95% confidence intervals (CI) of the Time effects are reported. Estimates for the Group*Time interaction effects, as well as estimates adjusted for age, sex, and medication use are presented in Additional file 2 (Table S5)

From: Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials

Region

Measure

Frequency band

Disease stage

β

95% CI

p-value

Temporal

Relative power

Theta

MCIb

2.2E-03

1.2E-03

3.1E-03

 < .001***

 

AD dementiab

8.2E-04

-3.1E-04

2.0E-03

0.16

Alpha1

MCIb

-3.7E-04

-1.3E-03

5.6E-04

0.44

 

AD dementiab

-6.0E-04

-1.7E-03

5.0E-04

0.30

Alpha2

MCIa

-2.5E-04

-8.4E-04

3.4E-04

0.41

 

AD dementiaa

-5.7E-04

-1.3E-03

1.1E-04

0.10

Beta

MCIa

-8.0E-04

-1.4E-03

-1.8E-04

 < .05*

 

AD dementiaa

-5.8E-04

-1.3E-03

1.5E-04

0.12

AEC-c

Alpha

MCIa

-1.6E-04

-5.8E-04

2.7E-04

0.47

 

AD dementiaa

-2.2E-05

-5.1E-04

4.7E-04

0.93

Beta

MCIa

-2.5E-05

-1.9E-04

1.4E-04

0.77

 

AD dementiaa

-5.2E-05

-2.5E-04

1.4E-04

0.60

PLI

Theta

MCIa

1.1E-04

-3.7E-04

5.8E-04

0.66

 

AD dementiaa

1.5E-04

-4.0E-04

7.1E-04

0.59

PE

Theta

MCIa

-9.2E-05

-3.0E-04

1.2E-04

0.39

 

AD dementiaa

-2.5E-04

-4.9E-04

-7.6E-06

 < .05*

wSMI

Theta

MCIa

1.5E-05

-1.4E-04

1.7E-04

0.85

 

AD dementiaa

1.5E-04

-2.8E-05

3.4E-04

0.10

JPEinv

Theta

MCIa

-5.0E-05

-1.7E-04

6.7E-05

0.40

 

AD dementiaa

-1.3E-04

-2.7E-04

6.9E-06

0.06

  1. AEC-c Corrected amplitude envelope correlation, PLI Phase lag index, PE Permutation entropy, wSMI Weighted symbolic mutual information, JPEinv Inverted joint permutation entropy
  2. *p<.05, **p<.01, ***p<.001 
  3. aRandom intercept on subject level
  4. bRandom intercept and random slope on subject level