Differential effects of cholesterol levels on cognition according to body mass index in Parkinson’s disease

Table 5 Cox regression analysis of the effects of total cholesterol levels on dementia conversion according to body mass index

Variables	Under-/normal weight (C-index = 0.816)		Overweight (C-index = 0.884)		Obese (C-index = 0.86)
Variables	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age at symptom onset	1.044 (0.981–1.110)	0.174	1.122 (1.003–1.256)	0.045	1.155 (1.009–1.322)	0.037
Female	0.206 (0.067–0.630)	0.006	0.263 (0.032–2.15)	0.213	0.171 (0.032–0.916)	0.039
Symptom duration	1.003 (0.975–1.031)	0.85	1.004 (0.969–1.041)	0.813	0.995 (0.933–1.062)	0.882
Education	1.011 (0.902–1.132)	0.856	0.970 (0.816–1.153)	0.727	0.846 (0.689–1.037)	0.107
MMSE score	0.633 (0.504–0.794)	< 0.001	0.907 (0.643–1.279)	0.577	0.912 (0.703–1.184)	0.490
Hypertension	0.718 (0.247–2.089)	0.543	9.886 (1.471–66.428)	0.018	2.497 (0.439–14.211)	0.302
Diabetes	1.229 (0.397–3.805)	0.720	0.076 (0.008–0.774)	0.030	1.370 (0.321–5.850)	0.671
Statin use	1.015 (0.393–2.619)	0.975	2.833 (0.575–13.961)	0.201	0.798 (0.204–3.123)	0.746
DAT-PP
WMHs burden	1.000 (0.955–1.048)	0.993	1.036 (0.963–1.115)	0.338	1.124 (1.019–1.241)	0.019
BMI	0.867 (0.612–1.230)	0.424	0.981 (0.303–3.181)	0.975	0.947 (0.556–1.613)	0.841
TC levels per 1 SD increase	0.550 (0.344–0.880)	0.013	0.908 (0.399–2.065)	0.818	2.085 (1.160–3.746)	0.014

Results of Cox regression analyses for PDD conversion after controlling for age at symptom onset, sex, symptom duration, years of education, MMSE scores, the presence of hypertension and diabetes, statin use, WMHs burden, BMI, and TC levels
BMI body mass index, CI confidence interval, DAT-PP dopamine transporter availability in the posterior putamen, HR hazard ratio, MMSE the Mini-Mental state Examination, TC total cholesterol, WMHs white matter hyperintensities

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