Alzheimer's Research & Therapy

Table 4 Cox regression analysis of the effects of total cholesterol levels on dementia conversion

From: Differential effects of cholesterol levels on cognition according to body mass index in Parkinson’s disease

Variables	Model 1 (C-index = 0.791)		Model 2 (C-index = 0.793)
Variables	HR (95% CI)	P	HR (95% CI)	P
Age at symptom onset	1.063 (1.023–1.105)	0.002	1.068 (1.027–1.111)	0.001
Female	0.381 (0.188–0.771)	0.007	0.367 (0.183–0.736)	0.005
Symptom duration	1.003 (0.984–1.023)	0.736	1.001 (0.981–1.02)	0.958
Education	0.999 (0.933–1.070)	0.973	0.997 (0.931–1.066)	0.919
MMSE score	0.808 (0.710–0.919)	0.001	0.795 (0.695–0.909)	0.001
Hypertension	1.333 (0.725–2.449)	0.355	1.439 (0.782–2.649)	0.242
Diabetes	0.864 (0.442–1.687)	0.668	0.774 (0.392–1.527)	0.459
Statin use	1.513 (0.799–2.866)	0.204	1.489 (0.790–2.807)	0.218
DAT-PP
WMHs burden	1.025 (0.991–1.061)	0.150	1.025 (0.991–1.061)	0.150
BMI	0.930 (0.837–1.033)	0.177	0.977 (0.872–1.096)	0.696
TC levels per 1 SD increase	0.863 (0.638–1.166)	0.336	0.015 (0.001–0.154)	< 0.001
BMI × TC levels	-	-	1.193 (1.081–1.317)	< 0.001

Results of Cox regression analyses for PDD conversion after controlling for age at symptom onset, sex, symptom duration, years of education, MMSE scores, the presence of hypertension and diabetes, statin use, WMHs burden, BMI, TC levels, and/or the interaction term of BMI*TC levels
BMI body mass index, CI confidence interval, DAT-PP dopamine transporter availability in the posterior putamen, HR hazard ratio, MMSE the Mini-Mental state Examination, TC total cholesterol, WMHs white matter hyperintensities

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ISSN: 1758-9193

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