Differential effects of cholesterol levels on cognition according to body mass index in Parkinson’s disease

Table 2 Interaction analyses for the association of total cholesterol levels with each cognitive domain

Cognitive domain	Attention/working memory		Language		Visuospatial		Memory		Frontal/executive
Variables	β (SE)	P	β (SE)	P	β (SE)	P	β (SE)	P	β (SE)	P
Intercept	-	-	-	-	-	-	-	-	0.413 (0.661)	0.533
Age	-	-	-	-	-	-	-	-	− 0.009 (0.006)	0.156
Female	-	-	-	-	-	-	-	-	0.141 (0.106)	0.185
Education	-	-	-	-	-	-	-	-	0.010 (0.011)	0.343
Symptom duration	-	-	-	-	-	-	-	-	− 0.001 (0.003)	0.764
Hypertension	-	-	-	-	-	-	-	-	0.085 (0.109)	0.435
Diabetes	-	-	-	-	-	-	-	-	− 0.224 (0.127)	0.079
Statin use	-	-	-	-	-	-	-	-	0.022 (0.111)	0.841
DAT-PP
WMHs burden	-	-	-	-	-	-	-	-	− 0.019 (0.007)	0.006
BMI	-	-	-	-	-	-	-	-	− 0.011 (0.018)	0.523
TC levels per 1 SD increase	-	-	-	-	-	-	-	-	1.220 (0.426)	0.004
BMI × TC levels	− 0.020 (0.018)	0.275	− 0.035 (0.022)	0.115	− 0.022 (0.038)	0.557	− 0.017 (0.017)	0.325	− 0.050 (0.018)	0.006

Interaction analyses were performed to investigate the interaction effect between total cholesterol levels and other dependent variables (age at symptom onset, sex, years of education, symptom duration, hypertension, diabetes, statin use, white matter hyperintensities, and BMI) on each cognitive domain. Each interaction analysis was performed after adjusting for age at symptom onset, sex, years of education, symptom duration, the presence of hypertension and diabetes, statin use, white matter hyperintensities, and BMI
β regression coefficient, BMI body mass index, DAT-PP dopamine transporter availability in the posterior putamen, SD standard deviation, SE standard error, TC total cholesterol, WMHs white matter hyperintensities
Bold indicates FDR-corrected P < 0.05

ISSN: 1758-9193