Fig. 3

Ability of plasma markers to detect changes in CSF. ROC curves of plasma biomarkers to detect amyloid status both individually (A) and combined (B) and Alzheimer pathology individually (C) and combined (D). The abscissa axis shows 1-specificity, and the ordinate axis shows sensitivity. The curves are based on the results of a logistic regression in which different markers and their combinations have been considered (see colors in the legend of each plot), adjusting the results for age and sex. Abbreviations: AD, Alzheimer’s disease; AUC, area under the curve; Aβ, amyloid beta; P-tau, phosphorylated tau; CI, confidence interval