Fig. 7

A receiver operating characteristic (ROC) curve showing a model of the mid-peripheral CFZ (periarteriole and perivenule CFZ) and multimodal model of the mid-peripheral CFZ, FAZ effective diameter, and vessel density to distinguish between low- and high-risk cognitively unimpaired older adults. The ROC model combining the periarteriole and perivenule CFZ width (mid-peripheral CFZs) is statistically significant, AUC = 0.65 (95% CI = 0.55–0.76), p = 0.006. Interestingly, the multimodal model which combined the mid-peripheral CFZs, FAZ effective diameter, and vessel density yielded a better model which is also statistically significant, AUC = 0.70 (95% CI = 0.60–0.80), p < 0.001