Independent effect of Aβ burden on cognitive impairment in patients with small subcortical infarction

Table 1 Demographic and clinical characteristics of the study participants

Group	Patients with stroke				CU without stroke (n = 37)	p^¥
Group	PSNC (n = 25)	PSCI (n = 12)	p*	Total (n = 37)	CU without stroke (n = 37)	p^¥
Demographics
Age, years	71.3 ± 8.0	74.7 ± 8.0	0.238	72.4 ± 8.1	72.6 ± 8.2	0.920
Sex, female	6 (24.0%)	6 (50.0%)	0.228	12 (32.4%)	13 (35.1%)	1.000
Education, years	9.4 ± 4.2	6.9 ± 5.1	0.128	8.6 ± 4.6	10.0 ± 4.8	0.196
APOE, e4 carrier	6 (24.0%)	7 (58.3%)	0.093	13 (35.1%)	7 (18.9%)	0.116
Hypertension	16 (64.0%)	11 (91.7%)	0.168	27 (73.0%)	17 (45.9%)	0.033
Diabetes	4 (16.0%)	7 (58.3%)	0.024	11 (29.7%)	11 (29.7%)	1.000
Cognition
K-MMSE	26.1 ± 3.8	22.3 ± 3.7	0.008	24.9 ± 4.1	27.9 ± 1.9	< 0.001
CDR-SOB	0.90 ± 0.54	2.71 ± 1.36	0.001	1.49 ± 1.22	0.20 ± 0.36	< 0.001
Aβ deposition
Aβ positivity	4 (16.0%)	7 (58.3%)	0.024	11 (29.7%)	6 (16.2%)	0.167
cSVD burden
WMH severity			0.228			0.010
Moderate WMH	5 (20.0%)	4 (33.3%)		9 (24.3%)	2 (5.4%)
Severe WMH	1 (4.0%)	2 (16.7%)		3 (8.1%)	0 (0.0%)
Lacune counts	0.7 ± 1.4	0.7 ± 1.1	0.977	0.7 ± 1.3	0.1 ± 0.3	0.006
MB counts	0.6 ± 1.4	0.6 ± 1.1	0.972	0.6 ± 1.3	0.4 ± 1.2	0.458
CAA markers
cSS	0 (0.0%)	0 (0.0%)		0 (0.0%)	0 (0.0%)
Strictly lobar MB	0 (0.0%)	0 (0.0%)		0 (0.0%)	0 (0.0%)

Values are presented as mean ± SD or n (%)
Abbreviations: Aβ Amyloid-β, APOE Apolipoprotein E, CDR-SOB Clinical Dementia Rating-Sum of Box, cSVD Cerebral small vessel disease, CU Cognitively unimpaired, K-MMSE Korean version of the Mini-Mental Status Examination, MB Microbleed, PSNC Post-stroke normal cognition, PSCI Post-stroke cognitive impairment, WMH White matter hyperintensity, SD Standard deviation
^*p-value was obtained by independent t-tests and chi-squared tests between the PSNC and PSCI groups
^¥p-value was obtained by independent t-tests and chi-squared tests between patients with stroke and CU without stroke groups

ISSN: 1758-9193