Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer’s disease

Table 2 Protein levels of proBDNF, BDNF, and humanin in NDEVs and panTET-EVs

Analyte	Source	Randomization	Visit	Number of samples	Mean^a (pg/mL)	95% confidence interval		Randomizationvisit univariate test (within groups)*				Randomizationvisit univariate test (between groups)*
Analyte	Source	Randomization	Visit	Number of samples	Mean^a (pg/mL)	Lower bound	Upper bound	Numerator df	Denominator df	F	Significance	Numerator df	Denominator df	F	Significance
proBDNF	NDEVs	Control	Baseline	38	148.79	60.81	236.76
		Control	16-week outcome	43	150.49	65.49	235.48	1	77.255	0.001	0.973
		Exercise	Baseline	44	139.679	56.29	223.06					1	130.961	0.022	0.882
		Exercise	16-week outcome	37	274.7	183.84	365.55	1	76.073	7.802	0.007	1	133.047	4.03	0.047
BDNF	NDEVs	Control	Baseline	37	5091.51	3159.8	7023.22
		Control	16-week outcome	43	5523.43	3631.36	7415.5	1	53.51	0.31	0.58
		Exercise	Baseline	43	3201.27	1319.87	5082.68					1	104.878	1.962	0.164
		Exercise	16-week outcome	36	4918.05	2926.75	6909.35	1	52.512	5.033	0.029	1	107.904	0.198	0.657
Humanin	NDEVs	Control	Baseline	38	232.83	147.9	317.77
		Control	16-week outcome	40	194.07	107.6	280.54	1	53.549	1.023	0.316
		Exercise	Baseline	44	91.88	10.04	173.72					1	102.06	5.626	0.02
		Exercise	16-week outcome	33	183.97	93.05	274.88	1	53.267	5.933	0.018	1	113.739	0.026	0.872
Humanin	panTET-EVs	Control	Baseline	38	465.86	316.19	615.52
		Control	16-week outcome	43	412.17	265.42	558.91	1	77.183	0.477	0.492
		Exercise	Baseline	44	313.12	169.76	456.48					1	127.573	2.139	0.146
		Exercise	16-week outcome	37	356.17	199.92	512.42	1	75.853	0.32	0.573	1	131.16	0.277	0.6

^a Estimated marginal means adjusted by age, sex, EV concentration, and APOE status
Correlations with P values in bold are statistically significant

ISSN: 1758-9193