Skip to main content

Table 3 Associations of SNAP-25 and Ng CSF levels with survival time in the whole CJD cohort and after stratification according to the disease subtype

From: Diagnostic and prognostic value of cerebrospinal fluid SNAP-25 and neurogranin in Creutzfeldt-Jakob disease in a clinical setting cohort of rapidly progressive dementias

Diagnostic group and biomarker

Survival time

Univariate Cox regression

Multivariate Cox regressiona

Median ± IQR (months)

HR (95% CI)

P value

HR (95% CI)

P value

Whole CJD cohort

 SNAP-25 (N = 215)

Continuous value

5.0 (2.8–12.0)

1.71 (1.48–1.99)

 < .001

1.71 (1.40–2.09)

 < .001

Low tertile

12.0 (6.0–17.5)

Ref

Ref

Ref

Ref

Mid tertile

4.0 (2.5–9.0)

1.87 (1.34–2.61)

 < .001

1.71 (1.19–2.44)

.003

High tertile

4.0 (2.5–5.5)

3.42 (2.38–4.90)

 < .001

3.42 (2.15–5.45)

 < .001

 Ng (N = 119)

Continuous value

6.0 (3.6–13.0)

1.19 (0.99–1.45)

.065

1.04 (0.82–1.33)

.720

Low tertile

7.5 (5.4–14.0)

Ref

Ref

Ref

Ref

Mid tertile

6.0 (3.5–11.8)

0.99 (0.63–1.54)

.971

0.80 (0.49–1.32)

.396

High tertile

4.1 (2.6–12.0)

1.23 (0.78–1.92)

.374

0.93 (0.54–1.60)

.808

Typical CJDb

 SNAP-25 (N = 100)

Continuous value

2.8 (2.1–4.0)

1.36 (1.03–1.80)

.029

1.52 (1.15–2.02)

.003

Low tertile

3.5 (2.4–4.1)

Ref

Ref

Ref

Ref

Mid tertile

2.5 (2.0–3.4)

0.94 (0.53–1.65)

.831

1.03 (0.56–1.77)

.991

High tertile

2.5 (2.1–3.3)

1.35 (0.76–2.39)

.302

1.65 (0.91–2.96)

.093

 Ng (N = 41)

Continuous value

3.0 (2.0–4.0)

1.50 (1.04–2.16)

.027

1.81 (1.21–2.93)

.015

Low tertile

2.4 (1.8–4.5)

Ref

Ref

Ref

Ref

Mid tertile

3.0 (2.1–3.8)

2.48 (0.70–8.76)

.157

7.90 (1.28–48.71)

.026

High tertile

3.0 (2.5–3.9)

3.59 (1.01–12.67)

.047

10.34 (1.71–62.34)

.011

non-MM(V)1 CJDc

 SNAP-25 (N = 115)

Continuous value

11.0 (6.0–16.0)

1.69 (1.38–2.06)

 < .001

1.01 (0.73–1.40)

.937

Low tertile

15.0 (11.0–24.0)

Ref

Ref

Ref

Ref

Mid tertile

14.8 (10.8–19.7)

1.39 (0.88–2.19)

.147

1.03 (0.58–1.83)

.914

High tertile

5.5 (4.7–6.5)

4.68 (2.81–7.78)

 < .001

0.91 (0.36–2.29)

.844

 Ng (N = 78)

Continuous value

9.5 (6.0–16.0)

0.93 (0.76–1.15)

.547

0.81 (0.60–1.09)

.169

Low tertile

9.0 (6.3–15.0)

Ref

Ref

Ref

Ref

Mid tertile

9.0 (5.9–15.5)

0.69 (0.41–1.15)

.164

0.58 (0.33–1.01)

.058

High tertile

12.0 (6.0–23.8)

0.50 (0.26–0.94)

.034

0.45 (0.22–0.91)

.027

  1. Bold values indicate statistically significant hazard ratios
  2. Abbreviations: CI confidence interval, CSF cerebrospinal fluid, gCJD genetic Creutzfeldt-Jakob disease, HR hazard ratio, IQR interquartile range, Ng neurogranin, Ref reference, sCJD sporadic Creutzfeldt-Jakob disease, SNAP-25 synaptosomal-associated protein 25
  3. aAll multivariate Cox regression analyses included codon 129 genotype, age at LP and time from onset to sample collection as covariates
  4. bIncludes sCJD MM(V)1 and gCJD M1
  5. cIncludes sCJD VV2, sCJD MV2K, sCJD MM(V)2C, sCJD MM2T, sCJD VV1, gCJD M “i”, gCJD M2T, and gCJD V1
Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193