Table 2 Diagnostic performance of SNAP-25, Ng, and other surrogate biomarkers
| Â | CJD vs. np-RPD | Atypical CJDa vs. np-RPD | ||||||
| Â | AUC (95% CI) | Sensitivity (95%CI) | Specificity (95% CI) | Cut-off (pg/ml) | AUC (95% CI) | Sensitivity (95%CI) | Specificity (95% CI) | Cut-off (pg/ml) |
t-tau | 0.878 (0.845–0.901) | 78.8% (72.9–83.7) | 84.9% (79.5–89.1) | 1770 | 0.774 (0.719–0.830) | 84.6% (73.9–91.4) | 63.8% (57.2–70.0) | 993.5 |
14–3-3 | 0.853 (0.816–0.889) | 83.8% (78.3–88.0) | 75.1% (68.9–80.4) | 21,750 | 0.733 (0.676–0.791) | 81.5% (70.4–9.1) | 65.7% (59.1–71.7) | 14,850 |
NfL | 0.649 (0.593–0.705) | 89.6% (84.9–92.9) | 51.9% (45.2–58.5) | 2245 | 0.626 (0.560–0.691) | 87.5% (77.2–93.5) | 51.8% (45.1–58.5) | 2245 |
SNAP-25 | 0.902 (0.873–0.931) | 84.7% (79.3–88.8) | 85.4% (80.0–89.5) | 198.7 | 0.792 (0.729–0.854) | 75.3% (63.6–84.2) | 78.4% (72.4–83.4) | 163.8 |
Ngb | 0.697 (0.626–0.767) | 54.1% (45.2–62.6) | 77.4% (67.9–84.7) | 793.5 | 0.643 (0.545–0.741) | 84.0% (70.6–92.0) | 46.2% (36.4–56.3) | 350.0 |
t-tau/p-tau | 0.884 (0.851–0.916) | 92.2% (87.8–95.0) | 70.4% (63.8–76.2) | 17.80 | 0.778 (0.725–0.830) | 98.4% (91.5–99.9) | 63.6% (56.8–69.8) | 11.90 |
SNAP-25/p-tau | 0.924 (0.900–0.948) | 92.2% (87.8–95.0) | 79.6% (73.6–84.5) | 2.950 | 0.812 (0.760–0.864) | 77.8% (66.0–86.2) | 79.6% (73.6–84.5) | 2.950 |
| Â | CJD vs. rp-ND | CJD vs. non-neurodegenerative np-RPD | ||||||
| Â | AUC (95% CI) | Sensitivity (95%CI) | Specificity (95% CI) | Cut-off (pg/ml) | AUC (95% CI) | Sensitivity (95%CI) | Specificity (95% CI) | Cut-off (pg/ml) |
t-tau | 0.928 (0.899–0.957) | 77.9% (72.0–82.9) | 94.0% (87.6–97.2) | 1808 | 0.826 (0.775–0.877) | 78.8% (72.9–83.7) | 76.5% (67.2–83.8) | 1768 |
14–3-3 | 0.942 (0.916–0.967) | 86.0% (80.8–89.9) | 91.0% (83.9–95.2) | 18,850 | 0.771 (0.712–0.831) | 83.8% (78.4–88.0) | 60.2% (50.3–69.3) | 21,750 |
NfL | 0.839 (0.782–0.896) | 89.6% (84.9–92.9) | 75.2% (66.0–82.6) | 2245 | 0.512 (0.429–0.595) | 90.0% (85.4–93.3) | 34.0% (25.4–43.9) | 15,450 |
SNAP-25 | 0.916 (0.886–0.946) | 80.6% (74.9–85.3) | 94.0% (87.6–97.2) | 214.2 | 0.887 (0.850–0.925) | 84.7% (79.4–88.8) | 81.6% (72.8–88.0) | 195.3 |
Ngb | 0.733 (0.652–0.813) | 54.1% (45.2–62.6) | 84.4% (71.2–92.2) | 787.0 | 0.669 (0.573–0.765) | 86.0% (78.8–91.1) | 46.5% (32.5–61.0) | 339.0 |
t-tau/p-tau | 0.966 (0.943–0.989) | 98.6% (96.0–99.6) | 88.0% (80.1–93.0) | 11.65 | 0.794 (0.736–0.851) | 63.7% (57.1–69.8) | 82.6% (73.6–89.0) | 51.40 |
SNAP-25/p-tau | 0.971 (0.954–0.987) | 92.2% (87.9–95.0) | 93% (86.2–96.6) | 2.950 | 0.869 (0.829–0.910) | 78.4% (72.5–83.3) | 83.7% (74.8–89.8) | 4.950 |