A polygenic risk score for Alzheimer’s disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.

Table 1 External GWAS used for AD PRS construction

GWAS name	Sample size (cases/controls)	Outcome	Race/ethnicity	Reference	Data download link
Kunkle et al. 2019 [17]	21,982 cases 41,944 controls (from stage 1)	AD	European ancestry	PMID: 30820047	https://www.niagads.org/datasets/ng00075
Kunkle et al., 2021 [13]	2,784 cases and 5,222 controls	AD	African ancestry	PMID: 33074286	https://www.niagads.org/datasets/ng00100
Bellenguez et al. [14]	39,106 cases, 46,828 proxy-AD cases and 401,577 controls	AD	European ancestry	PMID: 35379992	https://www.ebi.ac.uk/gwas/studies/GCST90027158
FINNGEN	7,759 cases, 334,740 controls	AD	Finnish European		https://www.FINNGEN.fi/en/access_results We used R8 GWAS version published on Dec, 1 2022
Jun et al. [15]	15,579 cases, 17,690 controls	AD	Multi-ethnic: European ancestry, African American, Japanese, and Israeli Arab	PMID: 28183528	https://www.niagads.org/datasets/ng00056
Lake et al. [42]	54,233 cases, 46,828 proxy-AD cases and 543,127	AD	Multi-ethnic: European ancestry, Finish European, East Asian, African ancestry, Caribbean Hispanic	PMID: 37198259	https://ndkp.hugeamp.org/dinspector.html?dataset=Lake2023_AD_Mixed

ISSN: 1758-9193