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Table 2 The AUCs for the four plasma biomarkers

From: Performance of plasma Aβ42/40, measured using a fully automated immunoassay, across a broad patient population in identifying amyloid status

 

AUC (confidence interval)

All

HC + MCI

HC only

N = 167

p-value

N = 99

p-value

N = 57

p-value

Aβ42/40

0.950 (0.917–0.983)

 

0.934 (0.882–0.987)

 

0.993 (0.977–1.009)

 

p-tau181

0.870 (0.812–0.929)

0.009

0.829 (0.741–0.918)

0.023

0.818 (0.623–1.014)

0.080

GFAP

0.834 (0.773–0.895)

0.001

0.818 (0.731–0.905)

0.009

0.745 (0.573–0.918)

0.006

NfL

0.679 (0.597–0.760)

< 0.001

0.711 (0.601–0.821)

< 0.001

0.701 (0.502–0.901)

0.003

  1. P-values designate the AUC difference from Aβ42/40 based on DeLong et al. [29]
  2. Abbreviations: AUC area under the curve, Aβ42/40 amyloid β 42/40 ratio, p-tau181 tau protein phosphorylated at residue 181, GFAP glial fibrillary acidic protein, NfL neurofilament light, HC healthy control, MCI mild cognitive impairment
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Alzheimer's Research & Therapy

ISSN: 1758-9193