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Table 4 Results from the interaction analyses between plasma protein levels and variables related to bone health and mood disorder for predicting overall cognitive function

From: A plasma protein signature associated with cognitive function in men without severe cognitive impairment

Exposure

Bcoeff

95% CI

t-value

p-value

aPartial eta-squared

Interaction between carboxypeptidase N catalytic chain and femoral neck BMD

 Carboxypeptidase N catalytic chain

0.20

− 0.02, 0.42

1.81

0.072

0.01

 Femoral neck BMD

0.19

− 0.29, 0.66

0.78

0.434

< 0.01

 Carboxypeptidase N catalytic chain#Femoral neck BMD

− 2.21

− 3.86, − 0.57

− 2.65

0.008

0.02

Interaction between glutathione peroxidase 3 and total hip BMD

 Glutathione peroxidase 3

0.36

0.12, 0.60

2.93

0.004

0.02

 Total hip BMD

0.23

− 0.19, 0.66

1.08

0.282

< 0.01

 Glutathione peroxidase 3#Total hip BMD

− 1.86

− 3.51, − 0.21

− 2.21

0.027

0.01

Interaction between apolipoprotein A-I and spine BMD

 Apolipoprotein A-I

0.38

0.11, 0.65

2.73

0.007

0.02

 Spine BMD

0.03

− 0.28, 0.35

0.20

0.840

< 0.01

 Apolipoprotein A-I#Spine BMD

1.49

0.08, 2.89

2.08

0.038

0.01

Interaction between apolipoprotein C-I and major osteoporotic fractures in the last 20 years

 Apolipoprotein C-I

0.18

0.04, 0.32

2.47

0.014

0.01

 MOF_20yrs

− 0.08

− 0.30, 0.15

− 0.66

0.510

< 0.01

Apolipoprotein C-I#MOF_20yrs

0.65

0.25, 1.06

3.19

0.002

0.02

Interaction between complement C1q subcomponent subunit B and major osteoporotic fractures in the last 20 years

 Complement C1q subcomponent subunit B

− 0.24

− 0.470, − 0.005

− 2.00

0.046

0.01

 MOF_20yrs

− 0.05

− 0.28, 0.18

− 0.45

0.654

< 0.01

 Complement C1q subcomponent subunit B#MOF_20yrs

− 1.52

− 2.45, − 0.59

− 3.21

0.001

0.02

Interaction between complement C1q subcomponent subunit C and major osteoporotic fractures in the last 20 years

 Complement C1q subcomponent subunit C

− 0.22

− 0.434, 0.001

− 1.95

0.051

0.01

 MOF_20yrs

− 0.05

− 0.28, 0.18

− 0.42

0.674

< 0.01

 Complement C1q subcomponent subunit C#MOF_20yrs

− 1.20

− 2.28, − 0.12

− 2.19

0.029

0.01

Interaction between apolipoprotein C-I and a current mood disorder

 Apolipoprotein C-I

− 0.02

− 0.42, 0.38

− 0.09

0.925

< 0.01

 Current mood disorder

0.03

− 0.30, 0.36

0.19

0.852

< 0.01

 Apolipoprotein C-I#Current mood disorder

0.81

0.05, 1.56

2.15

0.036

0.08

  1. The protein concentrations were transformed to a natural log, and the analyses were adjusted for age and APOE ε4 carrier status. The individual main effects are from a model without the interaction term. MOF_20yr refers to the occurrence of a major osteoporotic fracture in the last 20 years
  2. aAn eta-squared value of < 0.02 is considered a small effect size
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Alzheimer's Research & Therapy

ISSN: 1758-9193