A plasma protein signature associated with cognitive function in men without severe cognitive impairment

Mehta, Kanika; Mohebbi, Mohammadreza; Pasco, Julie A.; Williams, Lana J.; Sui, Sophia X.; Walder, Ken; Ng, Boon Lung; Gupta, Veer Bala

doi:10.1186/s13195-023-01294-7

Alzheimer's Research & Therapy

Table 3 Results from the interaction analyses between plasma protein levels and genetic variants for predicting overall cognitive function

From: A plasma protein signature associated with cognitive function in men without severe cognitive impairment

Exposure	B_coeff	95% CI	t-value	p-value	^aPartial eta-squared
Interaction between apolipoprotein C-I and rs3764650 (ABCA7)
Apolipoprotein C-I	0.17	0.03, 0.32	2.42	0.016	0.01
ABCA7_carrier	0.10	− 0.06, 0.26	1.27	0.204	< 0.01
Apolipoprotein C-I#ABCA7_carrier	− 0.44	− 0.83, − 0.05	− 2.24	0.026	0.01
Interaction between apolipoprotein C-I and rs11136000 (CLU)
Apolipoprotein C-I	0.17	0.03, 0.31	2.37	0.018	0.01
CLU_carrier	− 0.001	− 0.12, 0.12	− 0.02	0.986	< 0.01
Apolipoprotein C-I#CLU_carrier	− 0.29	− 0.58, − 0.01	− 2.00	0.046	0.01
Interaction between complement C1q subcomponent subunit C and rs6265 (BDNF)
Complement C1q subcomponent subunit C	− 0.22	− 0.438, − 0.005	− 2.01	0.045	0.01
BDNF_carrier	− 0.01	− 0.13, 0.12	− 0.10	0.919	< 0.01
Complement C1q subcomponent subunit C#BDNF_carrier	− 0.58	− 1.06, − 0.11	− 2.43	0.015	0.01
Interaction between glutathione peroxidase 3 and rs610932 (MS4A6A)
Glutathione peroxidase 3	0.28	0.04, 0.51	2.29	0.023	0.01
MS4A6A_carrier	− 0.02	− 0.15, 0.10	− 0.38	0.707	< 0.01
Glutathione peroxidase 3#MS4A6A_carrier	− 0.64	− 1.12, − 0.15	− 2.56	0.011	0.01
Interaction between lysozyme C and rs6265 (BDNF)
Lysozyme C	− 0.19	− 0.36, − 0.01	− 2.06	0.040	0.01
BDNF_carrier	− 0.01	− 0.14, 0.11	− 0.23	0.815	< 0.01
Lysozyme C#BDNF_carrier	− 0.36	− 0.71, − 0.01	− 2.00	0.047	0.01
Interaction between lysozyme C and rs610932 (MS4A6A)
Lysozyme C	− 0.18	− 0.36, − 0.01	− 2.05	0.041	0.01
MS4A6A_carrier	− 0.02	− 0.15, 0.10	− 0.39	0.696	< 0.01
Lysozyme C#MS4A6A_carrier	0.45	0.12, 0.79	2.65	0.008	0.02

The protein concentrations were transformed into a natural log, and the analyses were adjusted for age and APOE ε4 carrier status. The individual main effects are from a model without the interaction term
^aAn eta-squared value of < 0.02 is considered a small effect size

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