A plasma protein signature associated with cognitive function in men without severe cognitive impairment

Table 2 Results from the linear regression analysis investigating the association between plasma protein levels and overall cognitive function

Protein	B_coeff	95% CI	t-value	p-value	^aPartial eta-squared
Apolipoprotein A-I	0.38	0.11, 0.65	2.80	0.005	0.02
Apolipoprotein C-I	0.18	0.04, 0.32	2.46	0.014	0.01
Apolipoprotein M	0.23	< 0.01, 0.47	1.97	0.050	0.01
Carboxypeptidase N catalytic chain	0.22	< 0.01, 0.44	2.01	0.046	0.01
Complement C1q subcomponent subunit B	− 0.24	− 0.47, − 0.01	− 2.05	0.040	0.01
Complement C1q subcomponent subunit C	− 0.22	− 0.44, − 0.01	− 2.01	0.045	0.01
Glutathione peroxidase 3	0.28	0.04, 0.51	2.29	0.022	0.01
Lysozyme C	− 0.18	− 0.36, − 0.01	− 2.06	0.040	0.01
Neuropilin-2/cystatin-C	− 0.21	− 0.41, − 0.01	− 2.02	0.044	0.01
Alpha-1-microglobulin/bikunin precursor	− 0.19	− 0.373, − 0.004	− 2.01	0.045	0.01

The protein concentrations were transformed into a natural log, and the analyses were adjusted for age and APOE ε4 carrier status
^aAn eta-squared value of < 0.02 is considered a small effect size

ISSN: 1758-9193