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Table 4 Numerical results of SPM comparisons of FDG uptake in CG vs. CSFAβ42 + /amyR − , CSFAβ42 + /amyR − vs. CSFAβ42 + /amyR + , and CSFAβ42 + /amyR + vs. A + T + 

From: Different associations between amyloid-βeta 42, amyloid-βeta 40, and amyloid-βeta 42/40 with soluble phosphorylated-tau and disease burden in Alzheimer’s disease: a cerebrospinal fluid and fluorodeoxyglucose-positron emission tomography study

Analysis

Cluster level

Voxel level

 

Cluster p (FWE-corr)

Cluster p (FDR-corr)

Cluster extent

Cortical region

Z score of maximum

Talairach coordinates

Cortical region

BA

CG vs CSFAβ42 + /amyR − 

0.000

0.000

31,175

L parietal lobe

Inf

 − 36, − 74, 38

Precuneus

19

 

L temporal lobe

Inf

 − 52, − 56, − 10

Middle temporal gyrus

37

L parietal lobe

7.63

 − 48, − 48, 44

Inferior parietal lobule

40

0.001

0.000

1795

L frontal lobe

3.81

 − 26, 10, 58

Middle frontal gyrus

6

 

L frontal lobe

3.61

 − 30, 26, 46

Middle frontal gyrus

8

L frontal Lobe

3.43

 − 48, 30, 16

Inferior frontal gyrus

46

CSFAβ42 + /amyR − vs CSFAβ42 + /amyR + 

0.000

0.000

6851

R frontal lobe

5.06

14, 62, 0

Medial frontal gyrus

10

 

R frontal lobe

4.63

8, 60, 14

Medial frontal gyrus

10

R limbic lobe

4.58

16, 32, 18

Anterior cingulate

32

CSFAβ42 + /amyR + vs A + T + 

n.s

n.a

n.a

n.a

n.a

n.a

  1. In the “cluster level” section (left), the number of voxels, corrected p-value of significance, and cortical region where the voxel is found are all reported for each significant cluster. In the “voxel level” section, all the coordinates of the correlation sites (with the Z-score of the maximum correlation point), the corresponding cortical region and BA are reported for each significant cluster (CG, control group; Inf., infinite; L, left; R, right; BA, Brodmann area). When the maximum correlation is achieved outside the gray matter, the nearest gray matter (within a range of 5 mm) is indicated by the corresponding BA