Table 1 Baseline characteristics of study population by IGF-1 quartile

Age (years)

55.8 (8.1)

56.2 (8.0)

55.9 (8.1)

55.7 (8.1)

55.4 (8.2)

Sex

 Male

166,779 (45.1%)

41,753 (45.1%)

41,705 (45.1%)

41,651 (45.1%)

41,670 (45.1%)

 Female

202,932 (54.9%)

50,807 (54.9%)

50,777 (54.9%)

50,654 (54.9%)

50,694 (54.9%)

Ethnicity

 White

347,429 (94.0%)

86,048 (93.0%)

87,074 (94.2%)

87,122 (94.4%)

87,185 (94.4%)

 Non-White

20,542 (5.6%)

5,999 (6.5%)

4,986 (5.4%)

4,761 (5.2%)

4,796 (5.2%)

 Missing

1,740 (0.5%)

513 (0.6%)

422 (0.5%)

422 (0.5%)

383 (0.4%)

Educational attainment

 College or university degree

123,653 (33.4%)

27,587 (29.8%)

30,832 (33.3%)

323,71 (35.1%)

32,863 (35.6%)

 Professional qualifications

184,291 (49.8%)

46,735 (50.5%)

46,242 (50.0%)

45,476 (49.3%)

45,838 (49.6%)

 Others

57,544 (15.6%)

16,981 (18.3%)

14,407 (15.6%)

13,457 (14.6%)

12,699 (13.7%)

 Missing

4,223 (1.1%)

1,257 (1.4%)

1,001 (1.1%)

1,001 (1.1%)

964 (1.0%)

Townsend deprivation index

-1.35 (3.06)

-1.02 (3.20)

-1.34 (3.06)

-1.49 (2.98)

-1.57 (2.95)

Smoking status

 Never

207,190 (56.0%)

48,716 (52.6%)

51,201 (55.4%)

52,820 (57.2%)

54,453 (59.0%)

 Former

122,361 (33.1%)

32,073 (34.7%)

30,990 (33.5%)

30,087 (32.6%)

29,211 (31.6%)

 Current

38,392 (10.4%)

11,226 (12.1%)

9,840 (10.6%)

8,990 (9.7%)

8,336 (9.0%)

 Missing

1,768 (0.5%)

545 (0.6%)

451 (0.5%)

408 (0.4%)

364 (0.4%)

Alcohol frequency

 Daily or almost

75,188 (20.3%)

20,944 (22.6%)

19,755 (21.4%)

18,364 (19.9%)

16,125 (17.5%)

 3–4 times/week

86,867 (23.5%)

19,811 (21.4%)

21,978 (23.8%)

22,781 (24.7%)

22,297 (24.1%)

 1–2 times/week

96,128 (26.0%)

21,602 (23.3%)

23,824 (25.8%)

24,590 (26.6%)

26,112 (28.3%)

 1–3 times/month

41,355 (11.2%)

9,915 (10.7%)

10,098 (10.9%)

10,292 (11.2%)

11,050 (12.0%)

 Occasionally

41,300 (11.2%)

11,308 (12.2%)

9,961 (10.8%)

9,729 (10.5%)

10,302 (11.2%)

 Never

28,052 (7.6%)

8,703 (9.4%)

6,657 (7.2%)

6,362 (6.9%)

6,330 (6.9%)

 Missing

821 (0.2%)

277 (0.3%)

209 (0.2%)

187 (0.2%)

148 (0.2%)

Body mass index (kg/m²)

27.3 (4.7)

28.2 (5.5)

27.3 (4.7)

26.9 (4.3)

26.7 (4.0)

Vegetable and fruit intake (serving/day)

4.68 (3.04)

4.51 (3.06)

4.65 (3.01)

4.73 (3.01)

4.84 (3.08)

Hypertension

256,146 (69.3%)

65,902 (71.2%)

63,641 (68.8%)

63,146 (68.4%)

63,457 (68.7%)

Diabetes

16,089 (4.4%)

5,856 (6.3%)

3,556 (3.8%)

3,194 (3.5%)

3,483 (3.8%)

Total cholesterol (mmol/L)

5.76 (1.11)

5.73 (1.13)

5.79 (1.10)

5.79 (1.10)

5.74 (1.10)

C-reactive protein (mg/L)

2.51 (4.18)

3.42 (5.02)

2.49 (3.89)

2.17 (3.70)

1.95 (3.79)