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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to AppNL−G−F knock-in Alzheimer mice

Fig. 3

Schematic representation of the ECB implantation into mouse hippocampus, ECB brain parenchymal localization and BDNF release pre- and post-implantation. A Schematic representation of the bilateral implantation of ECB device in mouse hippocampi. B Representation of the Study outline using cohort 1 mice. C Level of BDNF release from the ECB-BDNF devices during pre-implantation (pre-impl.) and post-explantation (post-expl.). Data are represented as mean ± S.E.M. and analyzed by unpaired Student’s t-test. D Representative ECB localization in mouse brain stained with H&E, E its integration to brain parenchyma stained with H&E, and F distribution of cells around the ECB devices as stained with Hoechst

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Alzheimer's Research & Therapy

ISSN: 1758-9193