Fig. 4

Distribution of NODDI metric z-scores across CU A − T − and A + T + CST AT status participants for all ROIs. For cognitively unimpaired participants, boxplots display the median, 25th quartile, and 75th quartile NDI or ODI z-scores and NDI or ODI values, respectively, for each ROI across A − T − or A + T + CSF A/T status groups. NODDI-NDI and NODDI-ODI z-scores were developed using robust normative analysis in R as described. CSF A/T status cutoffs were determined by ROC analysis as described. Box plot color corresponds to CSF A/T status (gray = A − T − ; blue = A + T +). ODI or NDI z-scores are labeled on the left Y-axis. On the right Y-axis are the raw NDI or ODI values corresponding to each z-score quartile. * indicates a significant difference in NDI z-score distribution between clinical diagnosis groups. “*” = P < 0.05, “**” = P < 0.01, “***” = P < 0.001, Kruskal–Wallis)