Table 2 Linear regression results: Association of APOE4, Kunkle PRS, and Bellenguez PRS with blood-based biomarkers, P-tau181, NfL, & GFAP
Predictor | n | P-tau181 beta (p-value) | NfL beta (p-value) | GFAP beta (p-value) |
|---|---|---|---|---|
n total | 712 | |||
APOE4 – | 486 | Ref | Ref | Ref |
APOE4 + | 224 | 0.06 (.11) | -0.04 (.15) | 0.07 (.049) |
Kunkle PRS | ||||
Q1 | 156 | Ref | Ref | Ref |
Q2 | 188 | 0.03 (.58) | -0.07 (.07) | 0.03 (.58) |
Q3 | 167 | -0.01 (.81) | -0.08 (.06) | 0.009 (.87) |
Q4 | 201 | -0.01 (.83) | -0.06 (.12) | 0.08 (.11) |
Bellenguez PRS | ||||
Q1 | 148 | Ref | Ref | Ref |
Q2 | 184 | 0.03 (.54) | -0.08 (.06) | 0.04 (.42) |
Q3 | 187 | -0.02 (.72) | -0.08 (.07) | 0.05 (.35) |
Q4 | 193 | -0.008 (.88) | -0.03 (.41) | 0.12 (0.20) |
Kunkle PRS per SD increase | 712 | 0.004 (.82) | 0.01 (.43) | .05 (.008) |
Bellenguez PRS per SD increase | 712 | 0.005 (.78) | -0.02 (.11) | 0.03 (.07) |