Table 1 Descriptive statistics of the study cohort stratified by patient group
Repetitive head impact/ traumatic encephalopathy syndrome (RHI/TES) | Healthy controls | MCI/dementia due to AD | |||
|---|---|---|---|---|---|
Aβ( −) | Aβ( +) | All RHI/TES | |||
N | 22 | 11 | 33 | 59 | 62 |
Age, years | 58.5 (12.1) | 67.5 (7.6) | 61.5 (11.5) | 73.0 (6.2) | 67.1 (10.2) |
Sex, N (%) Female | 0 (0) | 0 (0) | 0 (0) | 35 (60) | 32 (52) |
Education, years | 16.6 (1.8) | 17.1 (1.4) | 16.8 (1.7) | 17.3 (2.3) | 16.8 (2.6) |
Self-reported race, N (%) | |||||
White | 18 (82) | 10 (91) | 28 (85) | 53 (90) | 52 (84) |
Black | 3 (14) | 1 (9) | 4 (12) | 1 (2) | 2 (3) |
Asian | 0 (0) | 0 (0) | 0 (0) | 2 (3) | 6 (10) |
Multiple | 1 (5) | 0 (0) | 1 (3) | 3 (5) | 2 (3) |
APOE genotype, N (%) e4 | 2 (10) | 3 (27) | 5 (15) | 10 (17) | 32 (58) |
CDR-sum of boxes | 4.0 (3.1) | 4.8 (2.6) | 4.3 (2.9) | 0.0 (0.1) | 3.9 (2.3) |
CDR + FTLD sum of boxes | 5.3 (4.2) | 6.1 (3.3) | 5.6 (3.9) | 0.0 (0.0) | 4.4 (2.8) |
CDR-global | |||||
0 | 3 (14) | 0 (0) | 3 (9) | 59 (100) | 0 (0) |
0.5 | 15 (68) | 4 (36) | 19 (58) | 0 (0) | 37 (60) |
1.0 + | 4 (18) | 7 (64) | 11 (33) | 0 (0) | 25 (40) |
Mini-Mental State Exam | 26.2 (2.5) | 23.5 (7.0) | 25.2 (4.7) | 29.3 (0.7) | 22.9 (5.2) |
American football, N (%) | 20 (91) | 10 (91) | 30 (91) | - | - |
Years of exposure | 12.4 (6.4) | 15.4 (3.8) | 13.4 (5.8) | - | - |
Aβ-PET, Centiloidsa | 0.4 (16.7) | 23.5 (24.3) | 8.1 (22.0) | 1.4 (10.3) | 91.1 (34.6) |
Tau-PET (flortaucipir) | |||||
N | 12 | 6 | 18 | - | 43 |
Metatemporal ROI SUVR | 1.16 (0.09) | 1.56 (0.48) | 1.31 (0.35) | - | 2.01 (0.55) |
SUVR > 1.27, N(%) | 1 | 4 | 5 | - | 40 |