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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Alzheimer’s pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome

Fig. 2

Voxel-based morphometry analyses comparing brain volume between repetitive head impact/traumatic encephalopathy syndrome (RHI/TES) study groups and healthy controls. Statistically significant volume differences (p < .001 uncorrected, voxel cluster minimum = 30) are represented by the red to yellow color spectrum, with the yellow end of the scale indicating greater (lower) volume difference from controls. Compared to controls, greatest and most consistent regional volume differences were in the anterior and medial temporal lobes regardless of Aβ status. Only Aβ( −) RHI/TES appeared to have lower thalamus volume than controls (white arrows). We did not observe statistically significant volume differences when comparing Aβ( +) to Aβ( −) RHI/TES or when comparing participants with RHI/TES to participants with AD

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Alzheimer's Research & Therapy

ISSN: 1758-9193