Total | CN | MCIa | AD dementia | |
---|---|---|---|---|
Number (%) | 133 (100.0) | 71 (53.4) | 41 (30.8) | 21 (15.8) |
Age, years, median (IQR) | 74.0 (71.0 to 78.0) | 74.0 (71.0 to 78.0) | 74.0 (68.5 to 77.0) | 76.0 (72.5 to 82.0) |
Body mass index, kg/m2, n (%) | ||||
< 25 (normal) | 87 (65.4) | 46 (64.8) | 25 (61.0) | 16 (76.2) |
≥ 25 (overweight or obese) | 46 (34.6) | 25 (35.2) | 16 (39.0) | 5 (23.8) |
Sex, female (%) | 68 (51.1) | 36 (52.9) | 22 (53.7) | 10 (47.6) |
Education, years, median (IQR) | 12.0 (6.0 to 14.0) | 9.0 (6.0 to 12.5) | 12.0 (6.0 to 13.0) | 10.0 (6.0 to 16.0) |
Household income, n (%) | ||||
Low (1–29 percentile) | 30 (22.6) | 12 (16.9) | 11 (26.8) | 7 (33.3) |
Middle (30–69 percentile) | 58 (43.6) | 30 (42.3) | 20 (48.8) | 8 (38.1) |
High (70–100 percentile) | 45 (33.8) | 29 (40.8) | 10 (24.4) | 6 (28.6) |
Smoking status, n (%) | ||||
Never or ex-smoker | 127 (95.5) | 68 (95.8) | 40 (97.6) | 19 (90.5) |
Current smoker | 6 (6.0) | 3 (3.2) | 1 (1.8) | 2 (0.9) |
Charlson comorbidity index, n (%) | ||||
0 | 53 (39.8) | 32 (45.1) | 12 (29.3) | 9 (42.9) |
1 | 50 (37.6) | 26 (52.0) | 18 (36.0) | 6 (28.6) |
≥ 2 | 30 (22.6) | 13 (18.3) | 11 (26.8) | 6 (28.6) |
APOE4 carrier, n (%) | 59 (44.3) | 17 (23.9) | 29 (70.7) | 13 (61.9) |
Mini-Mental State Examination score, median (IQR) | 27.0 (24.0 to 28.0) | 28.0 (27.0 to 29.0) | 26.0 (24.0 to 28.0) | 21.0 (16.0 to 24.0) |
Cognitive measure, composite z score, mean (SD) | ||||
SNSB attention score | − 0.32 (0.96) | − 0.01 (0.90) | − 0.60 (0.85) | − 0.90 (0.95) |
SNSB language and related function score | 0.07 (1.49) | 0.55 (0.66) | − 0.01 (1.13) | − 1.96 (2.91) |
SNSB visuospatial function score | 0.21 (2.34) | 0.96 (0.72) | 0.19 (1.58) | − 2.38 (4.62) |
SNSB memory score | − 0.36 (1.70) | 0.65 (0.99) | − 0.97 (1.48) | − 2.70 (1.15) |
SNSB frontal/executive function score | − 0.26 (2.01) | 0.56 (0.78) | − 0.66 (1.02) | − 2.33 (1.43) |
Amyloid PET, standard uptake value ratio, mean (SD) | 1.16 (0.29) | 1.06 (0.30) | 1.25 (0.25) | 1.35 (0.23) |
Hippocampal volume, cm3, mean (SD) | 7.25 (1.28) | 7.67 (0.95) | 7.04 (1.43) | 6.18 (1.26) |