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Table 3 Pathological markers of Alzheimer’s disease according to the breathing cessation events

From: Breathing cessation events that compose the apnea–hypopnea index are distinctively associated with the adverse outcomes in Alzheimer’s disease

 

Effect size (95% CI)

p-value

Obstructive apnea index

 Aβ42

0.108 (− 0.086 to 0.302)

0.276

 T-tau

0.035 (− 0.161 to 0.231)

0.723

 P-tau

0.011 (− 0.185 to 0.207)

0.915

 NF-L

0.252 (0.013 to 0.491)

0.042

 P-tau/Aβ42

 − 0.028 (− 0.226 to 0.17)

0.782

Central apnea index

 Aβ42

0.022 (− 0.19 to 0.234)

0.84

 T-tau

0.148 (− 0.064 to 0.36)

0.172

 P-tau

0.052 (− 0.162 to 0.266)

0.634

 NF-L

0.09 (− 0.126 to 0.306)

0.414

 P-tau/Aβ42

0.023 (− 0.193 to 0.239)

0.832

Mixed apnea index

 Aβ42

0.019 (− 0.171 to 0.209)

0.848

 T-tau

 − 0.017 (− 0.207 to 0.173)

0.859

 P-tau

0.027 (− 0.163 to 0.217)

0.785

 NF-L

0.229 (0.043 to 0.415)

0.019

 P-tau/Aβ42

0.013 (− 0.179 to 0.205)

0.898

Hypopnea index

 Aβ42

 − 0.109 (− 0.309 to 0.091)

0.289

 T-tau

 − 0.033 (− 0.235 to 0.169)

0.748

 P-tau

0.2 (0.002 to 0.398)

0.051

 NF-L

 − 0.08 (− 0.310 to 0.150)

0.49

 P-tau/Aβ42

0.217 (0.017 to 0.417)

0.035

  1. Linear regression models adjusted by age, sex, and BMI representing the pathological markers of AD according to the breathing cessation events that compose the AHI
  2. AD Alzheimer’s disease, AHI apnea–hypopnea index, Aβ42 amyloid-beta protein, BMI body mass index, CI confidence interval, NF-L neurofilament light, P-tau phosphorylated-tau, T-tau total-tau
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Alzheimer's Research & Therapy

ISSN: 1758-9193