Alzheimer's Research & Therapy

Table 2 Sleep structure according to the breathing cessation events

From: Breathing cessation events that compose the apnea–hypopnea index are distinctively associated with the adverse outcomes in Alzheimer’s disease

	Effect size (95% CI)	p-value
Obstructive apnea index
N1	0.334 (0.165 to 0.503)	< 0.001
N2	0.104 (− 0.084 to 0.292)	0.281
SWS	− 0.227 (− 0.405 to − 0.049)	0.014
REM sleep	− 0.059 (− 0.251 to 0.133)	0.549
Arousals	0.78 (0.651 to 0.909)	< 0.001
Central apnea index
N1	0.289 (0.120 to 0.457)	0.001
N2	− 0.151 (− 0.337 to 0.035)	0.113
SWS	− 0.082 (− 0.262 to 0.098)	0.377
REM sleep	− 0.063 (− 0.253 to 0.127)	0.518
Arousals	0.173 (− 0.013 to 0.359)	0.071
Mixed apnea index
N1	0.199 (0.024 to 0.373)	0.026
N2	0.145 (− 0.041 to 0.331)	0.128
SWS	− 0.053 (− 0.233 to 0.127)	0.565
REM sleep	0.071 (− 0.119 to 0.261)	0.464
Arousals	0.425 (0.254 to 0.595)	< 0.001
Hypopnea index
N1	0.029 (− 0.149 to 0.207)	0.747
N2	0.135 (− 0.051 to 0.321)	0.158
SWS	− 0.123 (− 0.305 to 0.059)	0.188
REM sleep	− 0.094 (− 0.286 to 0.098)	0.335
Arousals	0.521 (0.356 to 0.685)	< 0.001

Linear regression models adjusted by age, sex, and BMI representing the sleep structure according to the breathing cessation events that compose the AHI
AHI apnea–hypopnea index, BMI body mass index, CI confidence interval, SWS slow-wave sleep

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ISSN: 1758-9193

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