REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals

Table 2 Multiple linear regressions between REM sleep characteristics and basal forebrain volume

Dependent variable	Independent variables	Unstandardized coefficient (95% CI)	Standard Error	Standardized coefficient	P_unc	P_{FDR-corrected}
Ch1-2–3 volume	REM-S percentage	0.2 (-0.55 – 0.95)	0.38	0.06	0.59
	REM-S latency	-4.14 (-19.4 – 11.13)	7.62	-0.06	0.59
	REM-S efficiency	-0.04 (-0.35 – 0.28)	0.16	-0.03	0.82
Ch4 volume	REM-S percentage	0.003 (8.9e⁻⁴ – 0.006)	0.001	0.32	0.009	0.03
	REM-S latency	-0.04 (-0.09 – 0.01)	0.03	-0.19	0.13
	REM-S efficiency	2.6e⁻⁴ (-8.4e⁻⁴ – 0.001)	5.5e⁻⁴	0.06	0.64
Total BF volume	REM-S percentage	2.33 (0.38 – 4.28)	0.97	0.27	0.02	0.06
	REM-S latency	-29.03 (-69.89 – 11.82)	20.4	-0.16	0.16
	REM-S efficiency	0.09 (-0.76 – 0.94)	0.43	0.02	0.84

Results of multiple regressions performed with REM sleep variables (i.e., REM sleep percentage, latency and efficiency) as predictors, and the volume of BF subregions (i.e., Ch1-2–3, Ch4 and the total BF) as outcomes, controlling for age, sex and the total intracranial volume. Results indicated in bold survive an FDR correction for multiple comparisons
Abbreviations: BF basal forebrain, CI confidence interval, FDR false discovery rate, REM-S rapid eye movement sleep

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