Fig. 3
From: Pathogenesis of miR-155 on nonmodifiable and modifiable risk factors in Alzheimer’s disease
Pathogenesis of miR-155 in AD-related adaptive immune. CD3 + T cells can get access to the brain parenchyma via injured BBB. CD8 + T cells mainly differentiate into cytotoxic T lymphocytes (CTL). MiR-155 can regulate CD8 + T cells by regulating FoxO3a negatively. CD4 + T cells eliminate infected target cells indirectly by interacting with microglia. miR-155 promotes Th1 cell polarization by targeting IFNγRα, SOCS1, and SHIP1. Moreover, miR-155 can regulate the migration, differentiation, and function of Th2 cell by mediating S1PR1, PU.1, and c-Maf respectively. And miR-155 can facilitate Treg cell development via TGFβ signaling pathway. The activated microglia have different effects due to its phenotype