Fig. 1
From: Pathogenesis of miR-155 on nonmodifiable and modifiable risk factors in Alzheimer’s disease
Neuropathogenesis of miR-155 in AD. miR-155 regulates the deposition of Aβ by inducing SKP2 or SNX27. miR-155 might be involved in NFT by regulating GSK3β, AMPK, PKI-α, mTOR, MAPK, or Wnt pathways, which evolves from assembled hyperphosphorylated tau protein and induces synaptic dysfunction. miR-155 was also involved in synaptic dysfunction by regulating c/EBPβ/SNX27 signaling pathway. miR-155 can activate microglia via targeting SOCS-1 or SHIP1. The activated microglia can phagocytize aggregated Aβ but also can release pro-inflammatory cytokine, which accelerates Aβ aggregation and leads to neuroinflammation