Plasma apolipoprotein E levels, isoform composition, and dimer profile in relation to plasma lipids in racially diverse patients with Alzheimer’s disease and mild cognitive impairment

Table 5 Significant correlations between plasma total apoE, apoE isoforms levels, and plasma lipids in Black/African-American and non-Hispanic white APOE ε3/ε4 subjects

Race/ ethnicity	ApoE isoform	t-Ch (mmol/L)	LDL (mmol/L)	Total plasma apoE (μg/mL)	Plasma apoE3 (μg/mL)
Whole cohort (n = 46)	apoE3	ns	ns	ρ = 0.965 (0.938, 0.980), p < 0.001	–
Whole cohort (n = 46)	apoE4	r = 0.473 (0.212, 0.671), p < 0.001	ns	r = 0.597 (0.371, 0.756), p < 0.001	ρ = 0.529 (0.283, 0.710), p < 0.001
B/AAs (n = 20)	apoE3	ns	ns	ρ = 0.984 (0.960, 0.993), p < 0.001	–
B/AAs (n = 20)	apoE4	r = 0.645 (0.283, 0.846), p = 0.002	r = 0.552 (0.145, 0.799), p = 0.012	ρ = 0.750 (0.461, 0.895), p < 0.001	ρ = 0.677 (0.335, 0.861), p = 0.001
NHWs (n = 26)	apoE3	ns	ns	r = 0.958 (0.907, 0.981), p < 0.001	–
NHWs (n = 26)	apoE4	ns	ns	r = 0.605 (0.284, 0.804), p < 0.001	ns

Correlation analysis was performed using Pearson’s (r) correlation test or Spearman’s (ρ) rank coefficient test. Numbers in brackets correspond to 95% confidence intervals
B/AAs Black/African-Americans, NHWs Non-Hispanic whites, apoE Apolipoprotein E, t-Ch. Total cholesterol, LDL Low-density lipoprotein, ns Non-significant

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