White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

Table 8 Hyperactivity subsyndrome analyses

	0.1514 (32/500)	0.1905 (30/500)	0.1738 (56/500)	0.1445 (29/500)	0.1585 (30/500)	0.1659 (54/500)	0.1819 (51/500)
(Intercept)	8.521	7.047	7.636	8.876	8.179	7.911	7.348
MoCA TOTAL	− 0.067	− 0.057	− 0.061	-0.069	− 0.065	− 0.063	− 0.059
LH FUSIFORM THICKNESS	− 0.022	0.000	0.000	− 0.034	− 0.010	− 0.001	0.000
LH ROSTRAL ANTERIOR CINGULATE THICKNESS	− 0.174	− 0.138	− 0.154	− 0.180	− 0.167	− 0.161	− 0.146
LH SUPERIOR TEMPORAL THICKNESS	− 0.372	− 0.360	− 0.369	− 0.369	− 0.373	− 0.373	− 0.364
LH INSULA THICKNESS	− 0.057	− 0.047	− 0.055	− 0.051	− 0.061	− 0.058	− 0.051
RH CAUDAL ANTERIOR CINGULATE THICKNESS	− 0.436	− 0.308	− 0.362	− 0.460	− 0.412	− 0.387	− 0.336
RH LATERAL ORBITOFRONTAL THICKNESS	− 0.158	− 0.174	− 0.169	− 0.155	− 0.163	− 0.166	− 0.171
RH MEDIAL ORBITOFRONTAL THICKNESS	− 0.244	− 0.128	− 0.177	− 0.264	− 0.222	− 0.643	− 0.153
RH PARS-TRIANGULARIS THICKNESS	− 0.698	− 0.558	− 0.616	− 0.724	− 0.670	− 0.593	− 0.587
RH TEMPORAL POLE THICKNESS	− 0.077	− 0.047	− 0.060	− 0.081	− 0.072	− 0.067	− 0.054
RBGT WMH	0.011	0.000	0.000	0.024	0.000	0.000	0.000

Row names indicate variables selected, column names indicate the lambda parameter and how many times out of 500 repeats that the lambda parameter had the lowest mean square error for our repeated cross-validation. Values in the cells are coefficients from the full data sample for the corresponding selected variables (rows) under the penalisation parameter (columns)
MoCA Montreal Cognitive Assessment, LH Left hemisphere, RBGT WMH Right basal ganglia/thalamus white matter hyperintensities, RH Right hemisphere

ISSN: 1758-9193