White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

Ozzoude, Miracle; Varriano, Brenda; Beaton, Derek; Ramirez, Joel; Adamo, Sabrina; Holmes, Melissa F.; Scott, Christopher J. M.; Gao, Fuqiang; Sunderland, Kelly M.; McLaughlin, Paula; Goubran, Maged; Kwan, Donna; Roberts, Angela; Bartha, Robert; Symons, Sean; Tan, Brian; Swartz, Richard H.; Abrahao, Agessandro; Saposnik, Gustavo; Masellis, Mario; Lang, Anthony E.; Marras, Connie; Zinman, Lorne; Shoesmith, Christen; Borrie, Michael; Fischer, Corinne E.; Frank, Andrew; Freedman, Morris; Montero-Odasso, Manuel; Kumar, Sanjeev; Pasternak, Stephen; Strother, Stephen C.; Pollock, Bruce G.; Rajji, Tarek K.; Seitz, Dallas; Tang-Wai, David F.; Turnbull, John; Dowlatshahi, Dar; Hassan, Ayman; Casaubon, Leanne; Mandzia, Jennifer; Sahlas, Demetrios; Breen, David P.; Grimes, David; Jog, Mandar; Steeves, Thomas D. L.; Arnott, Stephen R.; Black, Sandra E.; Finger, Elizabeth; Rabin, Jennifer; Tartaglia, Maria Carmela

doi:10.1186/s13195-023-01257-y

Alzheimer's Research & Therapy

Table 7 Affective subsyndrome analyses

From: White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

	1000 (89/500)	0.0525 (44/500)	0.0479 (24/500)	0.0631 (34/500)	0.0661 (31/500)	0.0603 (34/500)	0.0575 (48/500)	0.0549 (42/500)
(Intercept)	0.800	3.419	3.553	3.124	3.046	3.200	3.275	3.348
AGE	0.000	− 0.008	− 0.009	− 0.006	− 0.006	− 0.007	− 0.007	− 0.008
Sex(female)	0.000	− 0.121	− 0.134	− 0.090	− 0.082	− 0.098	− 0.106	− 0.113
Sex(Male)	0.000	0.009	0.011	− 0.004	0.003	0.006	0.007	0.008
MoCA TOTAL	0.000	− 0.033	− 0.034	− 0.029	− 0.027	− 0.030	− 0.031	− 0.032
LH LATERAL OCCIPITAL THICKNESS	0.000	0.614	0.657	0.519	0.492	0.544	0.566	0.591
LH LATERAL ORBITOFRONTAL THICKNESS	0.000	0.345	0.420	0.173	0.127	0.217	0.261	0.305
LH LINGUAL THICKNESS	0.000	0.424	0.442	0.384	0.375	0.393	0.405	0.414
LH PERICALCARINE THICKNESS	0.000	0.111	0.140	0.040	0.019	0.059	0.078	0.095
LH POSTERIOR CINGULATE THICKNESS	0.000	− 0.118	− 0.146	− 0.048	− 0.027	− 0.067	− 0.086	− 0.103
LH SUPERIOR TEMPORAL THICKNESS	0.000	0.000	− 0.002	0.000	0.000	0.000	0.000	0.000
RH CAUDAL ANTERIOR CINGULATE THICKNESS	0.000	− 0.279	− 0.299	− 0.233	− 0.218	− 0.246	− 0.258	− 0.269
RH MIDDLE TEMPORAL THICKNESS	0.000	− 0.019	− 0.035	0.000	0.000	0.000	0.000	− 0.009
RH PARS-TRIANGULARIS THICKNESS	0.000	− 0.726	− 0.761	− 0.633	− 0.602	− 0.622	− 0.687	− 0.707
RH TEMPORAL POLE THICKNESS	0.000	− 0.107	− 0.122	− 0.072	− 0.059	− 0.083	− 0.091	− 0.100
RH INSULA THICKNESS	0.000	− 0.040	− 0.060	0.000	0.000	− 0.004	− 0.018	− 0.028
RP WMH	0.000	− 0.002	− 0.005	0.000	0.000	0.000	0.000	0.000
LO WMH	0.000	− 0.050	− 0.055	− 0.036	− 0.032	− 0.040	− 0.044	− 0.048
RBGT WMH	0.000	0.197	0.211	0.169	0.161	0.176	0.183	0.190

Row names indicate variables selected, column names indicate the lambda parameter and how many times out of 500 repeats that the lambda parameter had the lowest mean square error for our repeated cross-validation. Values in the cells are coefficients from the full data sample for the corresponding selected variables (rows) under the penalisation parameter (columns)
MoCA Montreal Cognitive Assessment, LH Left hemisphere, LO WMH Left occipital white matter hyperintensities, RBGT WMH Right basal ganglia/thalamus white matter hyperintensities, RH Right hemisphere

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ISSN: 1758-9193

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