White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

Table 6 Apathy subsyndrome analyses

	0.0661 (25/500)	0.0832 (28/500)	0.0794 (50/500)	0.0955 (28/500)	0.0759 (40/500)	0.0724 (38/500)	0.0871 (55/500)
(Intercept)	8.188	7.115	7.338	6.430	7.550	7.767	6.893
AGE	− 0.017	− 0.013	− 0.014	− 0.010	− 0.014	− 0.015	− 0.012
Sex(female)	− 0.030	0.000	− 0.006	0.000	− 0.013	− 0.019	0.000
MoCA TOTAL	− 0.059	− 0.054	− 0.055	− 0.051	− 0.057	− 0.058	− 0.053
LH CUNEUS THICKNESS	− 0.042	0.000	0.000	0.000	0.000	− 0.013	0.000
LH ROSTRAL MIDDLE FRONTAL THICKNESS	− 0.494	− 0.450	− 0.460	− 0.405	− 0.470	− 0.478	− 0.439
LH FRONTALPOLE THICKNESS	− 0.097	− 0.055	− 0.065	− 0.018	− 0.074	− 0.082	− 0.043
LH TRANSVERSETEMPORAL THICKNESS	− 0.080	− 0.017	− 0.034	0.000	− 0.051	− 0.064	0.000
RH ENTORHINAL THICKNESS	− 0.146	− 0.108	− 0.116	− 0.079	− 0.124	− 0.131	− 0.099
RH ISTHMUS CINGULATE THICKNESS	− 0.055	− 0.008	− 0.018	0.000	− 0.028	− 0.037	0.000
RH MEDIAL ORBITOFRONTAL THICKNESS	− 0.040	− 0.009	− 0.016	0.000	− 0.023	− 0.029	− 0.002
RH MIDDLE TEMPORAL THICKNESS	− 0.454	− 0.475	− 0.471	− 0.491	− 0.467	− 0.464	− 0.482
RH PARS-OPERCULARIS THICKNESS	− 0.097	− 0.045	− 0.057	− 0.008	− 0.069	− 0.080	− 0.033
RH PARS-TRIANGULARIS THICKNESS	− 0.509	− 0.514	− 0.513	− 0.496	− 0.511	− 0.510	− 0.511
RH TRANSVERSETEMPORAL THICKNESS	− 0.019	0.000	0.000	0.000	0.000	− 0.001	0.000
LF WMH	− 0.023	− 0.005	− 0.009	0.000	− 0.012	− 0.016	− 0.001

Row names indicate variables selected, column names indicate the lambda parameter and how many times out of 500 repeats that the lambda parameter had the lowest mean square error for our repeated cross-validation. Values in the cells are coefficients from the full data sample for the corresponding selected variables (rows) under the penalisation parameter (columns)
MoCA Montreal Cognitive Assessment, LH Left hemisphere, LF WMH Left frontal white matter hyperintensities, RH Right hemisphere

ISSN: 1758-9193